Synthesis of [14C] quincetone

被引：0
|
作者：
Li Yu-guo
Huang Xuan
Liu Riu-li
Li Qing-nuan
Zhang Xiao-dong
Li Wen-xin
机构：
[1] Laboratory of Nanoscale Biomedicine,
[2] Shanghai Institute of Applied Physics,undefined
[3] Chinese Academy of Sciences,undefined
[4] Laboratory of Nanoscale Biomedicine,undefined
[5] Shanghai Institute of Applied Physics,undefined
[6] Chinese Academy of Sciences,undefined
[7] Laboratory of Nanoscale Biomedicine,undefined
[8] Shanghai Institute of Applied Physics,undefined
[9] Chinese Academy of Sciences,undefined
[10] Laboratory of Nanoscale Biomedicine,undefined
[11] Shanghai Institute of Applied Physics,undefined
[12] Chinese Academy of Sciences,undefined
[13] Shanghai Jiaotong University of Chinese,undefined
[14] Laboratory of Nanoscale Biomedicine,undefined
[15] Shanghai Institute of Applied Physics,undefined
[16] Chinese Academy of Sciences,undefined
来源：
Journal of Radioanalytical and Nuclear Chemistry | 2005年 / 265卷 / 1期
关键词：
Physical Chemistry; Bone Marrow; Reaction Time; Inorganic Chemistry; Fullerene;
D O I：
10.1007/s10967-005-0802-x
中图分类号：
学科分类号：
摘要：
The water-soluble fullerene derivative C60(OH)x was radiolabeled with 67GaCl3. The labeling yields were determined by radio-PLC. The effects of pH, reaction time, temperature and the amount of C60(OH)x on the labeling yields were studied. The stability of 67Ga-C60(OH)x was also examined. The results showed that the labeling yields could reach 97% under the best labeling conditions and the radiochemical purity of 67Ga-C60(OH)x solution kept at 37 °C remained at 88% after 212 hours. The biodistribution studies of 67Ga-C60(OH)x in mice showed a high localization of 67Ga-C60(OH)x in the bone marrow, bone, liver and spleen with slow clearance and a negligible accumulation in the blood. These data suggest that the water-soluble C60(OH)x, having the same properties as microcolloids, may be used as a carrier of drug system for lymphatic targeting.
引用
收藏
页码：127 / 131
页数：4
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