To inhibit or to boost the ATP/P2RX7 pathway to fight cancer—that is the question

被引：0
|
作者：
Serena Janho dit Hreich
Jonathan Benzaquen
Paul Hofman
Valérie Vouret-Craviari
机构：
[1] Université Côte D’Azur,Laboratory of Clinical and Experimental Pathology and Biobank
[2] CNRS,undefined
[3] INSERM,undefined
[4] IRCAN,undefined
[5] FHU OncoAge,undefined
[6] Centre Antoine Lacassagne,undefined
[7] Pasteur Hospital,undefined
[8] Hospital-Related Biobank (BB-0033-00025),undefined
[9] Pasteur Hospital,undefined
来源：
Purinergic Signalling | 2021年 / 17卷
关键词：
Purinergic signaling; P2X7; Immunotherapies; Tumors; Antitumor immunity; Ectonucleases;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Despite new biological insights and recent therapeutic advances, many tumors remain at baseline during treatments. Therefore, there is an urgent need to find new therapeutic strategies to improve the care of patients with solid tumors. P2RX7 receptor (P2XR7), an ATP-gated ion channel characterized by its ability to form large pore within the cell membrane, is described by most of the investigators as a “chef d’orchestre” of the antitumor immune response. The purpose of this review is to detail the recent information concerning different cellular mechanisms linking P2RX7 to hallmarks of cancer and to discuss different progresses in elucidating how activation of the ATP/P2RX7/NLRP3/IL-18 pathway is a very promising approach to fight cancer progression by increasing antitumor immune responses.
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收藏
页码：619 / 631
页数：12
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