To inhibit or to boost the ATP/P2RX7 pathway to fight cancer—that is the question

被引：0
|
作者：
Serena Janho dit Hreich
Jonathan Benzaquen
Paul Hofman
Valérie Vouret-Craviari
机构：
[1] Université Côte D’Azur,Laboratory of Clinical and Experimental Pathology and Biobank
[2] CNRS,undefined
[3] INSERM,undefined
[4] IRCAN,undefined
[5] FHU OncoAge,undefined
[6] Centre Antoine Lacassagne,undefined
[7] Pasteur Hospital,undefined
[8] Hospital-Related Biobank (BB-0033-00025),undefined
[9] Pasteur Hospital,undefined
来源：
Purinergic Signalling | 2021年 / 17卷
关键词：
Purinergic signaling; P2X7; Immunotherapies; Tumors; Antitumor immunity; Ectonucleases;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Despite new biological insights and recent therapeutic advances, many tumors remain at baseline during treatments. Therefore, there is an urgent need to find new therapeutic strategies to improve the care of patients with solid tumors. P2RX7 receptor (P2XR7), an ATP-gated ion channel characterized by its ability to form large pore within the cell membrane, is described by most of the investigators as a “chef d’orchestre” of the antitumor immune response. The purpose of this review is to detail the recent information concerning different cellular mechanisms linking P2RX7 to hallmarks of cancer and to discuss different progresses in elucidating how activation of the ATP/P2RX7/NLRP3/IL-18 pathway is a very promising approach to fight cancer progression by increasing antitumor immune responses.
引用
收藏
页码：619 / 631
页数：12
相关论文
共 50 条
  • [31] P2RX7 at the Host-Pathogen Interface of Infectious Diseases
    Soare, Alexandra Y.
    Freeman, Tracey L.
    Min, Alice K.
    Malik, Hagerah S.
    Osota, Elizabeth O.
    Swartz, Talia H.
    MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS, 2021, 85 (01)
  • [32] Exonic variants of the P2RX7 gene in familial multiple sclerosis
    Gomez-Pinedo, U.
    Torre-Fuentes, L.
    Matias-Guiu, J. A.
    Pytel, V.
    Ojeda-Hernandez, D. D.
    Selma-Calvo, B.
    Montero-Escribano, P.
    Vidorreta-Ballesteros, L.
    Matias-Guiu, J.
    NEUROLOGIA, 2025, 40 (02): : 150 - 160
  • [33] Associations of P2RX7 Functional Diplotypes with Localized Aggressive Periodontitis
    Harris, T. H.
    Wallace, M. R.
    Huang, H.
    Li, H.
    Shaddox, L. M.
    JDR CLINICAL & TRANSLATIONAL RESEARCH, 2019, 4 (04) : 342 - 351
  • [34] Characterization of P2rX7 knockout in PCK (Polycystic Kidney) rats
    Arkhipov, Sergey N.
    Potter, D'Anna
    Geurts, Aron M.
    Pavlov, Tengis S.
    FASEB JOURNAL, 2018, 32 (01):
  • [35] Flow cytometry: An accurate tool for screening P2RX7 modulators
    Barczyk, Amelie
    Roy, Helene Bauderlique-Le
    Jouy, Nathalie
    Renault, Nicolas
    Hottin, Audrey
    Millet, Regis
    Vouret-Craviari, Valerie
    Adriouch, Sahil
    Idziorek, Thierry
    Dezitter, Xavier
    CYTOMETRY PART A, 2021, 99 (08) : 793 - 806
  • [36] P2RX7 Purinoceptor as a Therapeutic Target-The Second Coming?
    Young, Chris N. J.
    Gorecki, Dariusz C.
    FRONTIERS IN CHEMISTRY, 2018, 6
  • [37] P2RX7 DEFICIENCY OR P2RX7 ANTAGONISM BLUNTS ANGIOTENSIN II-INDUCED HYPERTENSION, VASCULAR INJURY AND CD8+T CELL ACTIVATION
    Paradis, Pierre
    Shokoples, Brandon
    Berillo, Olga
    Comeau, Kevin
    Higaki, Akinori
    Caillon, Antoine
    Ferreira, Nathanne S.
    Schiffrin, Ernesto L.
    JOURNAL OF HYPERTENSION, 2023, 41 : E272 - E272
  • [38] The nucleotide receptor P2RX7 mediates ATP-induced CREB activation in human and murine monocytic cells
    Gavala, Monica L.
    Pfeiffer, Zachary A.
    Bertics, Paul J.
    JOURNAL OF LEUKOCYTE BIOLOGY, 2008, 84 (04) : 1159 - 1171
  • [39] Dynamic Increase in Extracellular ATP Accelerates Photoreceptor Cell Apoptosis via Ligation of P2RX7 in Subretinal Hemorrhage
    Notomi, Shoji
    Hisatomi, Toshio
    Murakami, Yusuke
    Terasaki, Hiroto
    Sonoda, Shozo
    Asato, Ryo
    Takeda, Atsunobu
    Ikeda, Yasuhiro
    Enaida, Hiroshi
    Sakamoto, Taiji
    Ishibashi, Tatsuro
    PLOS ONE, 2013, 8 (01):
  • [40] Evidence for associations between the purinergic receptor P2X7 (P2RX7) and toxoplasmosis
    Jamieson, S. E.
    Peixoto-Rangel, A. L.
    Hargrave, A. C.
    de Roubaix, L-A
    Mui, E. J.
    Boulter, N. R.
    Miller, E. N.
    Fuller, S. J.
    Wiley, J. S.
    Castellucci, L.
    Boyer, K.
    Peixe, R. G.
    Kirisits, M. J.
    de Souza Elias, L.
    Coyne, J. J.
    Correa-Oliveira, R.
    Sautter, M.
    Smith, N. C.
    Lees, M. P.
    Swisher, C. N.
    Heydemann, P.
    Noble, A. G.
    Patel, D.
    Bardo, D.
    Burrowes, D.
    McLone, D.
    Roizen, N.
    Withers, S.
    Bahia-Oliveira, L. M. G.
    McLeod, R.
    Blackwell, J. M.
    GENES AND IMMUNITY, 2010, 11 (05) : 374 - 383
12345