Pharmacokinetic/Pharmacodynamic Modelling and Simulation of Lusutrombopag, a Novel Thrombopoietin Receptor Agonist, for the Treatment of Thrombocytopenia in Patients with Chronic Liver Disease Undergoing Invasive Procedures

被引:0
|
作者
Takayuki Katsube
Ryosuke Shimizu
Takahiro Fukuhara
Takeshi Kano
Toshihiro Wajima
机构
[1] Clinical Pharmacology and Pharmacokinetics,Clinical Research Department
[2] Shionogi & Co.,Project Management Department
[3] Ltd,undefined
[4] Shionogi & Co.,undefined
[5] Ltd,undefined
[6] Shionogi & Co.,undefined
[7] Ltd,undefined
来源
Clinical Pharmacokinetics | 2019年 / 58卷
关键词
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
页码:1469 / 1482
页数:13
相关论文
共 50 条
  • [21] Lusutrombopag for treatment of thrombocytopenia in patients with chronic liver disease who are undergoing planned invasive procedures: pooled safety analysis of bleeding-related adverse events
    Giannini, Edoardo Giovanni
    Kano, Takeshi
    Ochiai, Toshimitsu
    Bentley, Roy
    Shrestha, Pomy
    [J]. JOURNAL OF HEPATOLOGY, 2019, 70 (01) : E643 - E643
  • [22] Lusutrombopag for Treatment of Thrombocytopenia in Patients With Chronic Liver Disease Who Are Undergoing Planned Invasive Procedures: Pooled Safety Analysis of Bleeding-Related Adverse Events
    Giannini, Edoardo G.
    Kano, Takeshi
    Ochiai, Toshimitsu
    Bentley, Roy
    Shrestha, Pomy
    [J]. AMERICAN JOURNAL OF GASTROENTEROLOGY, 2019, 114 : S550 - S550
  • [23] EFFECTIVENESS AND SAFETY OF THROMBOPOIETIN-RECEPTOR AGONIST LUSUTROMBOPAG FOR CHRONIC LIVER DISEASE PATIENTS WHO UNDERGO ELECTIVE INVASIVE PROCEDURES: RESULTS FROM A REAL-WORLD, MULTICENTER STUDY
    Taniki, Nobuhito
    Nakamoto, Nobuhiro
    Yamataka, Karin
    Yoshida, Aya
    Chu, Po-Sung
    Ikura, Akihiko
    Morikawa, Rei
    Komiyama, Yasuyuki
    Nagamatsu, Hiroaki
    Maruyama, Hitoshi
    Kanai, Takanori
    Shiina, Shuichiro
    [J]. HEPATOLOGY, 2019, 70 : 265A - 266A
  • [24] Real-world data demonstrate safety and effectiveness of lusutrombopag in chronic liver disease patients with thrombocytopenia undergoing planned invasive procedures: Interim analysis
    Afdhal, Nezam
    Shiino, Chikako
    Sasaki, Ritsue
    Bentley, Roy
    Cai, Bin
    [J]. JOURNAL OF HEPATOLOGY, 2019, 70 (01) : E626 - E626
  • [25] EFFICACY OF ORAL THROMBOPOIETIN RECEPTOR AGONIST LUSUTROMBOPAG IN CHRONIC LIVER DISEASE PATIENTS UNDERGOING A GASTROINTESTINAL PROCEDURE: RESULTS FROM TWO PHASE 3 CLINICAL TRIALS
    Moehlen, Martin
    Semaan, Mark
    Kano, Takeshi
    Ochiai, Toshimitsu
    [J]. GASTROENTEROLOGY, 2020, 158 (06) : S614 - S614
  • [26] Lusutrombopag is a safe treatment option for thrombocytopenia in patients with chronic liver disease undergoing an invasive procedure: Pooled safety analysis from 3 studies
    Afdhal, Nezam
    Brown, Robert
    Izumi, Namiki
    Kano, Takeshi
    Ochiai, Toshimitsu
    Kurosaki, Masayuki
    Violi, Francesco
    Shrestha, Pomy
    [J]. JOURNAL OF HEPATOLOGY, 2019, 70 (01) : E625 - E626
  • [27] Lusutrombopag Is a Safe Treatment Option for Thrombocytopenia in Patients With Chronic Liver Disease Undergoing a Scheduled Invasive Procedure: Pooled Safety Analysis From 3 Studies
    Brown, Robert S., Jr.
    Izumi, Namiki
    Kano, Takeshi
    Ochiai, Toshimitsu
    Kurosaki, Masayuki
    Violi, Francesco
    Shrestha, Pomy
    [J]. AMERICAN JOURNAL OF GASTROENTEROLOGY, 2019, 114 : S585 - S585
  • [28] Safety and effectiveness of lusutrombopag in patients who have chronic liver disease with thrombocytopenia and undergoing invasive procedures: Real-world post-marketing surveillance in Japan
    Yoshiji, Hitoshi
    Suzuki, Junto
    Imasaki, Masafumi
    Tsukimura, Eri
    Miyano, Makiko
    Kurosaki, Masayuki
    [J]. HEPATOLOGY RESEARCH, 2023, 53 (11) : 1105 - 1116
  • [29] Clinical Relevance of Thrombocytopenia in Patients With Advanced Liver Disease Undergoing Invasive Procedures
    Giannini, Edoardo G.
    Greco, Alfredo
    Andorno, Enzo
    Valente, Umberto
    Savarino, Vincenzo
    [J]. GASTROENTEROLOGY, 2010, 138 (05) : S819 - S819
  • [30] Is platelet monitoring during 7-day lusutrombopag treatment necessary in chronic liver disease patients with thrombocytopenia undergoing planned invasive procedures? A phase IIIb open-label study
    Numata, Kazushi
    Tanaka, Katsuaki
    Katsube, Takayuki
    Ochiai, Toshimitsu
    Fukuhara, Takahiro
    Kano, Takeshi
    Osaki, Yukio
    Izumi, Namiki
    Imawari, Michio
    [J]. HEPATOLOGY RESEARCH, 2020, 50 (10) : 1141 - 1150