Clonal expansions of CD8+ T cells in latently HSV-1-infected human trigeminal ganglia

被引：0
|
作者：
Kathrin Held
Ingrid Eiglmeier
Susanne Himmelein
Inga Sinicina
Thomas Brandt
Diethilde Theil
Klaus Dornmair
Tobias Derfuss
机构：
[1] University of Basel,Department of Neurology/Department of Biomedicine
[2] Ludwig Maximilian University,Institute of Clinical Neuroimmunology
[3] Max-Planck-Institute of Neurobiology,Institute of Neuroimmunology
[4] Ludwig Maximilian University,Department of Clinical Neurosciences
[5] Novartis Institute of Biomedical Research,Department of Legal Medicine
[6] IFB,undefined
[7] Ludwig Maximilian University,undefined
[8] Ludwig Maximilian University,undefined
来源：
Journal of NeuroVirology | 2012年 / 18卷
关键词：
HSV-1; Latency; CD8; T cells; Human; Trigeminal ganglia;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Herpes simplex virus type 1 latency in trigeminal ganglia (TG) is accompanied by a chronic immune cell infiltration. The aim of this study was to analyse the T-cell receptor β-chain repertoire in latently HSV-1 infected human TG. Using complementarity-determining region 3 spectratyping, 74 expanded β-chain sequences were identified in five TG. No clone appeared in more than one subject. Similar clones were present in the right and the left TG of two subjects. This indicates that these T cells are primed in the periphery and recognise the same antigen in the TG of both sides.
引用
收藏
页码：62 / 68
页数：6
相关论文
共 50 条
  • [41] Human regulatory CD8+ T cells
    Dempsey, Laurie A.
    NATURE IMMUNOLOGY, 2022, 23 (05) : 645 - 645
  • [42] Dendritic cells, macrophages, NK and CD8+ T lymphocytes play pivotal roles in controlling HSV-1 in the trigeminal ganglia by producing IL1-beta, iNOS and granzyme B
    Natália Lucinda
    Maria Marta Figueiredo
    Natália Lima Pessoa
    Beatriz Senra Álvares da Silva Santos
    Graciela Kunrath Lima
    Arthur Molinari Freitas
    Alexandre Magalhães Vieira Machado
    Erna Geessien Kroon
    Lis Ribeiro do Valle Antonelli
    Marco Antônio Campos
    Virology Journal, 14
  • [43] Dendritic cells, macrophages, NK and CD8+ T lymphocytes play pivotal roles in controlling HSV-1 in the trigeminal ganglia by producing IL1-beta, iNOS and granzyme B
    Lucinda, Natlia
    Figueiredo, Maria Marta
    Pessoa, Natalia Lima
    Alvares da Silva Santos, Beatriz Senra
    Lima, Graciela Kunrath
    Freitas, Arthur Molinari
    Vieira Machado, Alexandre Magalhaes
    Kroon, Erna Geessien
    do Valle Antonelli, Lis Ribeiro
    Campos, Marco Antonio
    VIROLOGY JOURNAL, 2017, 14
  • [44] A dichotomy of differentiated states in large clonal CD8+ T cell expansions of elderly humans
    Chamberlain, WD
    Kotzin, BL
    FASEB JOURNAL, 1999, 13 (05): : A1133 - A1133
  • [45] Clonal expansion of CD8+ effector T cells in childhood tuberculosis
    Jacobsen, Marc
    Detjen, Anne K.
    Mueller, Henrik
    Gutschmidt, Andrea
    Leitner, Sandra
    Wahn, Ulrich
    Magdorft, Klaus
    Kaufmann, Stefan H. E.
    JOURNAL OF IMMUNOLOGY, 2007, 179 (02): : 1331 - 1339
  • [46] Clonal predominance of CD8+ T cells in patients with unexplained neutropenia
    Wlodarski, Marcin Wojciech
    Nearman, Zachary
    Jiang, Ying
    Lichtin, Alan
    Maciejewski, Jaroslaw Pawel
    EXPERIMENTAL HEMATOLOGY, 2008, 36 (03) : 293 - 300
  • [47] Somatic mutations associate with clonal expansion of CD8+ T cells
    Lundgren, Sofie
    Myllymaki, Mikko
    Jarvinen, Timo
    Keraenen, Mikko A. I.
    Theodoropoulos, Jason
    Smolander, Johannes
    Kim, Daehong
    Salmenniemi, Urpu
    Walldin, Gunilla
    Savola, Paula
    Kelkka, Tiina
    Rajala, Hanna
    Hellstroem-Lindberg, Eva
    Itala-Remes, Maija
    Kankainen, Matti
    Mustjoki, Satu
    SCIENCE ADVANCES, 2024, 10 (23):
  • [48] γδ T17 Cells Regulate the Acute Antiviral Response of NK Cells in HSV-1-Infected Corneas
    Rodenberg, Rachel R.
    Spadafora, Domenico
    Fitzpatrick, Steffani
    Daly, Grant
    Lausch, Robert
    Barrington, Robert A.
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2024, 65 (13)
  • [49] Multiple sclerosis:: Brain-infiltrating CD8+ T cells persist as clonal expansions in the cerebrospinal fluid and blood
    Skulina, C
    Schmidt, S
    Dornmair, K
    Babbe, H
    Roers, A
    Rajewsky, K
    Wekerle, H
    Hohlfeld, R
    Goebels, N
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (08) : 2428 - 2433
  • [50] Regulation of CD8+ T cell effector function by herpes simplex virus latently infected neurons
    Hendricks, RL
    Prabhakaran, K
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2005, 46
12345