Clonal expansions of CD8+ T cells in latently HSV-1-infected human trigeminal ganglia

被引：0
|
作者：
Kathrin Held
Ingrid Eiglmeier
Susanne Himmelein
Inga Sinicina
Thomas Brandt
Diethilde Theil
Klaus Dornmair
Tobias Derfuss
机构：
[1] University of Basel,Department of Neurology/Department of Biomedicine
[2] Ludwig Maximilian University,Institute of Clinical Neuroimmunology
[3] Max-Planck-Institute of Neurobiology,Institute of Neuroimmunology
[4] Ludwig Maximilian University,Department of Clinical Neurosciences
[5] Novartis Institute of Biomedical Research,Department of Legal Medicine
[6] IFB,undefined
[7] Ludwig Maximilian University,undefined
[8] Ludwig Maximilian University,undefined
来源：
Journal of NeuroVirology | 2012年 / 18卷
关键词：
HSV-1; Latency; CD8; T cells; Human; Trigeminal ganglia;
D O I：
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中图分类号：
学科分类号：
摘要：
Herpes simplex virus type 1 latency in trigeminal ganglia (TG) is accompanied by a chronic immune cell infiltration. The aim of this study was to analyse the T-cell receptor β-chain repertoire in latently HSV-1 infected human TG. Using complementarity-determining region 3 spectratyping, 74 expanded β-chain sequences were identified in five TG. No clone appeared in more than one subject. Similar clones were present in the right and the left TG of two subjects. This indicates that these T cells are primed in the periphery and recognise the same antigen in the TG of both sides.
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页码：62 / 68
页数：6
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