Large-scale de novo DNA synthesis: Technologies and applications

被引：0
|
作者：
Kosuri S. [1 ]
Church G.M. [2 ,3 ]
机构：
[1] Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA
[2] Wyss Institute for Biologically Inspired Engineering, Boston, MA
[3] Department of Genetics, Harvard Medical School, Boston, MA
来源：
Nature Methods | 2014年 / 11卷 / 5期
关键词：
D O I：
10.1038/nmeth.2918
中图分类号：
学科分类号：
摘要：
For over 60 years, the synthetic production of new DNA sequences has helped researchers understand and engineer biology. Here we summarize methods and caveats for the de novo synthesis of DNA, with particular emphasis on recent technologies that allow for large-scale and low-cost production. In addition, we discuss emerging applications enabled by large-scale de novo DNA constructs, as well as the challenges and opportunities that lie ahead. © 2014 Nature America, Inc.
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收藏
页码：499 / 507
页数：8
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