Mathematical Modeling of Functioning of the p53–Mdm2 Protein System

被引：0
|
作者：
O. F. Voropaeva
Yu. I. Shokin
L. M. Nepomnyashchikh
S. R. Senchukova
机构：
[1] Siberian Division of the Russian Academy of Sciences,Institute of Computation Technologies
[2] Siberian Division of the Russian Academy of Medical Sciences,Research Institute of Regional Pathology and Pathomorphology
来源：
Bulletin of Experimental Biology and Medicine | 2014年 / 157卷
关键词：
p53-dependent apoptosis; p53–Mdm2 network; mathematical simulation;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Mathematical simulation of the time course of p53 and Mdm2 protein concentrations during their interactions was carried out. The system states corresponding to threatened uncontrolled apoptotic cell death accelerating aging processes and to situation with hypersuppression of p53-dependent apoptosis fraught with high risk of cancer were modeled. New data indicate the possibility of description (within the framework of mathematical model used in the study) of the p53 and Mdm2 proteins feedback mechanism, which could guarantee adequate reaction to serious DNA damage.
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页码：291 / 294
页数：3
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