The expression of MDM2 and p53 protein breast carcinoma

被引：0
|
作者：
Hideshima, T
Shinohara, T
Baba, M
Shirakusa, T
机构：
来源：
ONCOLOGY REPORTS | 1997年 / 4卷 / 02期
关键词：
MDM2; p53; estrogen receptor; breast carcinoma;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
We studied the expression of MDM2 protein and p53 protein in 67 cases of the breast carcinoma. The result demonstrated no significant relationship between the MDM2 protein expression and any of the clinicopathological parameters except for the estrogen receptor status (p=0.033). Furthermore, in p53 protein negative cases, there was a significant relationship between MDM2 protein expression and the ER status (p=0.027). This study showed the expression of ER to be associated with MDM2 protein in p53 protein negative breast carcinoma. These results thus suggested that an investigation of both p53 and MDM2 gene alteration revealed precise information regarding breast carcinoma.
引用
收藏
页码：297 / 300
页数：4
相关论文
共 50 条
  • [1] MDM2 and p53 protein expression in the histologic subtypes of endometrial carcinoma
    Ambros, RA
    Sheehan, CE
    Kallakury, BVS
    Ross, JS
    Malfetano, J
    Paunovich, E
    Figge, J
    [J]. MODERN PATHOLOGY, 1996, 9 (12) : 1165 - 1169
  • [2] p53 AND MDM2 PROTEIN EXPRESSION IN ACTINIC CHEILITIS
    Andrade de Freitas, Maria da Conceicao
    Pedreira Ramalho, Luciana Maria
    Aquino Xavier, Flavia Calo
    Gomes Moreira, Andre Luis
    Almeida Reis, Silvia Regina
    [J]. JOURNAL OF APPLIED ORAL SCIENCE, 2008, 16 (06) : 414 - 419
  • [3] p53 expression and relationship with MDM2 amplification in breast carcinomas
    Buyukpinarbasili, Nur
    Gucin, Zuhal
    Ersoy, Yeliz Emine
    Ilbak, Ayca
    Kadioglu, Huseyin
    Muslumanoglu, Mahmut
    [J]. ANNALS OF DIAGNOSTIC PATHOLOGY, 2016, 21 : 29 - 34
  • [4] Immunohistochemical expression of Mdm2 and p53 in penile verrucous carcinoma
    Ouban, A
    Dellis, J
    Salup, R
    Morgan, M
    [J]. ANNALS OF CLINICAL AND LABORATORY SCIENCE, 2003, 33 (01): : 101 - 106
  • [5] p53 and MDM2 expression in oral squamous cell carcinoma
    Matsumura, T
    Yoshihama, Y
    Kimura, T
    Shintani, S
    Alcalde, RE
    [J]. ONCOLOGY, 1996, 53 (04) : 308 - 312
  • [6] Expression of p53 and mdm2 mRNA and protein in colorectal carcinomas
    Broll, R
    Stark, A
    Windhövel, U
    Best, R
    Strik, MW
    Schimmelpenning, H
    Schwandner, O
    Kujath, P
    Bruch, HP
    Duchrow, M
    [J]. EUROPEAN JOURNAL OF CANCER, 1999, 35 (07) : 1083 - 1088
  • [7] MDM2/p53 protein expression in the development of colorectal adenocarcinoma
    Ghada Abdel-Fattah
    Boris Yoffe
    Bhuvaneswari Krishnan
    Vladimir Khaoustov
    Kamal Ltani
    [J]. Journal of Gastrointestinal Surgery, 2000, 4 : 109 - 114
  • [8] MDM2/p53 protein expression in the development of colorectal adenocarcinoma
    Abdel-Fattah, G
    Yoffe, B
    Krishnan, B
    Khaoustov, V
    Itani, K
    [J]. JOURNAL OF GASTROINTESTINAL SURGERY, 2000, 4 (01) : 109 - 114
  • [9] Mdm2 gene amplification in gastric cancer correlation with expression of mdm2 protein and p53 alterations
    Günther, T
    Schneider-Stock, R
    Häckel, C
    Kasper, HU
    Pross, M
    Hackelsberger, A
    Lippert, H
    Roessner, A
    [J]. MODERN PATHOLOGY, 2000, 13 (06) : 621 - 626
  • [10] MDM2 and p53 expression in ampullary adenocarcinomas
    Perysinakis, I.
    Leontara, V.
    Minaidou, E.
    Karambogias, C.
    Choreftaki, T.
    Zografos, G.
    Kouraklis, G.
    [J]. VIRCHOWS ARCHIV, 2015, 467 : S126 - S126
12345