Binding of an inhibitor of the p53/MDM2 interaction to MDM2

被引：55
|
作者：
Duncan, SJ [1 ]
Cooper, MA [1 ]
Williams, DH [1 ]
机构：
[1] Univ Cambridge, Dept Chem, Cambridge CB2 1EW, England
来源：
CHEMICAL COMMUNICATIONS | 2003年 / 03期
关键词：
D O I：
10.1039/b211889k
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The mode of action of the secondary metabolite chlorofusin, which antagonises the interaction between p53 and MDM2, involves direct binding to the N-terminal domain of MDM2.
引用
收藏
页码：316 / 317
页数：2
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