Clerodane Diterpenoids with Anti-hyperglycemic Activity from Tinospora crispa

被引：13

作者：

Gao Y. ^{[1
,2
,4
]}

Niu Y.-F. ^{[1
,3
,5
]}

Wang F. ^{[1
,4
]}

Hai P. ^{[2
,4
]}

Wang F. ^{[1
,4
]}

Fang Y.-D. ^{[4
]}

Xiong W.-Y. ^{[1
]}

Liu J.-K. ^{[1
,6
]}

机构：

[1] State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, Yunnan

[2] Department of Chemical Engineering, Yibin University, Yibin

[3] Graduate University of Chinese Academy of Sciences, Beijing

[4] BioBioPha Co., Ltd, Kunming

[5] Yunnan University, Kunming

[6] School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan

来源：

Natural Products and Bioprospecting | 2016年 / 6卷 / 5期

基金：

中国国家自然科学基金;

关键词：

Anti-hyperglycemia;

D O I：

10.1007/s13659-016-0109-3

中图分类号：

学科分类号：

摘要：

Abstract: Four new clerodane diterpenoids, tinosporols A–C (2–4) and tinosporoside A (5), together with six known analogues were isolated from the vines of Tinospora crispa. Their structures were established by extensive spectroscopic analysis. The relative configuration at C-12 in the known diterpenoid borapetoside E (1), the major component of the plant, was firstly established with the aid of molecular model. Compound 1 significantly reduced serum glucose levels at dose-dependent manners in alloxan-induced hyperglycemic mice and db/db type 2 diabetic mice. Graphical Abstract: [Figure not available: see fulltext.]. © 2016, The Author(s).

引用

页码：247 / 255

页数：8

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