Comparison of whole-genome bisulfite sequencing library preparation strategies identifies sources of biases affecting DNA methylation data

被引：0
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作者：
Nelly Olova
Felix Krueger
Simon Andrews
David Oxley
Rebecca V. Berrens
Miguel R. Branco
Wolf Reik
机构：
[1] Epigenetics Programme,Blizard Institute, Barts and The London School of Medicine and Dentistry
[2] The Babraham Institute,Centre for Trophoblast Research
[3] Bioinformatics Group,undefined
[4] The Babraham Institute,undefined
[5] Mass Spectrometry Facility,undefined
[6] The Babraham Institute,undefined
[7] Queen Mary University of London,undefined
[8] Wellcome Trust Sanger Institute,undefined
[9] University of Cambridge,undefined
[10] Present address: MRC Human Genetics Unit,undefined
[11] MRC Institute of Genetics and Molecular Medicine,undefined
[12] University of Edinburgh,undefined
来源：
Genome Biology | / 19卷
关键词：
WGBS; Biases; Artefacts; Bisulfite conversion; Degradation; DNA methylation; NGS; Polymerase; GC skew;
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