Monovalent vaccination with inactivated SARS-CoV-2 BA.5 protects hamsters against Omicron but not non-Omicron variants

被引：0
|
作者：
Chon Phin Ong
Kaiming Tang
Pak-Hin Hinson Cheung
Hongzhuo Zhang
Tze-Tung Tang
Yaqian Xue
Junjue Wang
Kelvin Kai-Wang To
Shuofeng Yuan
Zi-Wei Ye
Dong-Yan Jin
机构：
[1] The University of Hong Kong,School of Biomedical Sciences, Li Ka Shing Faculty of Medicine
[2] Pokfulam,State Key Laboratory of Emerging Infectious Diseases, Carol Yu Centre for Infection, Department of Microbiology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine
[3] The University of Hong Kong,Centre for Virology, Vaccinology and Therapeutics
[4] Pokfulam,Department of Infectious Disease and Microbiology
[5] Hong Kong Science and Technology Park,undefined
[6] Shatin,undefined
[7] The University of Hong Kong-Shenzhen Hospital,undefined
来源：
npj Vaccines | / 8卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
We compared the protective effects of inactivated SARS-CoV-2 vaccines derived from the ancestral and the currently circulating BA.5.2 strains against infection with multiple variants in Syrian golden hamsters. Vaccination with BA.5.2 effectively protected against infection with the Omicron subvariants including XBB.1, but not the Alpha or Delta variant. In contrast, hamsters vaccinated with the ancestral strain demonstrated decent neutralization activity against both the Omicron and non-Omicron variants. Our findings might instruct future design and formulation of SARS-CoV-2 vaccines.
引用
收藏
相关论文
共 50 条
  • [31] Virucidal efficacy of a novel silver-based disinfectant against SARS-CoV-2 Omicron BA.5
    Zani, Alberto
    Messali, Serena
    Caccuri, Francesca
    NEW MICROBIOLOGICA, 2023, 46 (01): : 60 - 64
  • [32] In vitro activity of therapeutic antibodies against SARS-CoV-2 Omicron BA.1, BA.2 and BA.5
    Franck Touret
    Cécile Baronti
    Boris Pastorino
    Paola Mariela Saba Villarroel
    Laetitia Ninove
    Antoine Nougairède
    Xavier de Lamballerie
    Scientific Reports, 12
  • [33] Comparative neutralisation profile of SARS-CoV-2 omicron subvariants BA.2.75 and BA.5
    Tan, Chee-Wah
    Lim, Beng-Lee
    Young, Barnaby E.
    Yeoh, Aileen Ying-Yan
    Yung, Chee-Fu
    Yap, Wee-Chee
    Althaus, Thomas
    Chia, Wan-Ni
    Zhu, Feng
    Lye, David Chien
    Wang, Lin-Fa
    LANCET MICROBE, 2022, 3 (12): : E898 - E898
  • [34] Early Detection of SARS-CoV-2 Omicron BA.4 and BA.5 in German Wastewater
    Wilhelm, Alexander
    Agrawal, Shelesh
    Schoth, Jens
    Meinert-Berning, Christina
    Bastian, Daniel
    Orschler, Laura
    Ciesek, Sandra
    Teichgraeber, Burkhard
    Wintgens, Thomas
    Lackner, Susanne
    Weber, Frank-Andreas
    Widera, Marek
    VIRUSES-BASEL, 2022, 14 (09):
  • [35] Neutralizing Immunity Against Antigenically Advanced Omicron BA.5 in Children After SARS-CoV-2 Infection
    Belongia, Edward A.
    Petrie, Joshua G.
    Feldstein, Leora R.
    Guan, Lizheng
    Halfmann, Peter J.
    King, Jennifer P.
    Neumann, Gabriele
    Pattinson, David
    Rolfes, Melissa A.
    Mclean, Huong Q.
    Kawaoka, Yoshihiro
    JOURNAL OF THE PEDIATRIC INFECTIOUS DISEASES SOCIETY, 2024, 13 (01) : 100 - 104
  • [36] Neutralizing response against SARS-CoV-2 Omicron BA.5 and XBB.1.5 in hemodialysis patients
    Affeldt, Patrick
    Brensing, Karl August
    Heger, Eva
    Wirtz, Maike
    Steger, Gertrud
    Koehler, Felix Carlo
    Benzing, Thomas
    Stippel, Dirk
    Klein, Florian
    Kurschat, Christine
    Mueller, Roman-Ulrich
    Di Cristanziano, Veronica
    CLINICAL KIDNEY JOURNAL, 2023, 16 (12) : 2757 - 2759
  • [37] Emergence of SARS-CoV-2 Omicron lineages BA.4 and BA.5 in South Africa
    Tegally, Houriiyah
    Moir, Monika
    Everatt, Josie
    Giovanetti, Marta
    Scheepers, Cathrine
    Wilkinson, Eduan
    Subramoney, Kathleen
    Makatini, Zinhle
    Moyo, Sikhulile
    Amoako, Daniel G.
    Baxter, Cheryl
    Althaus, Christian L.
    Anyaneji, Ugochukwu J.
    Kekana, Dikeledi
    Viana, Raquel
    Giandhari, Jennifer
    Lessells, Richard J.
    Maponga, Tongai
    Maruapula, Dorcas
    Choga, Wonderful
    Matshaba, Mogomotsi
    Mbulawa, Mpaphi B.
    Msomi, Nokukhanya
    Naidoo, Yeshnee
    Pillay, Sureshnee
    Sanko, Tomasz Janusz
    San, James E.
    Scott, Lesley
    Singh, Lavanya
    Magini, Nonkululeko A.
    Smith-Lawrence, Pamela
    Stevens, Wendy
    Dor, Graeme
    Tshiabuila, Derek
    Wolter, Nicole
    Preiser, Wolfgang
    Treurnicht, Florette K.
    Venter, Marietjie
    Chiloane, Georginah
    McIntyre, Caitlyn
    O'Toole, Aine
    Ruis, Christopher
    Peacock, Thomas P.
    Roemer, Cornelius
    Kosakovsky Pond, Sergei L.
    Williamson, Carolyn
    Pybus, Oliver G.
    Bhiman, Jinal N.
    Glass, Allison
    Martin, Darren P.
    NATURE MEDICINE, 2022, 28 (09) : 1785 - +
  • [38] Bivalent omicron (BA.1) booster vaccination against SARS-CoV-2
    Vasin, Andrey V.
    Stukova, Marina A.
    LANCET INFECTIOUS DISEASES, 2023, 23 (08): : 880 - 881
  • [39] Viral load of SARS-CoV-2 Omicron BA.5 is lower than that of BA.2 despite the higher infectivity of BA.5
    Takatsuki, Yuna
    Takahashi, Yuta
    Nakajima, Jun
    Iwasaki, Yumi
    Nagano, Katsutoshi
    Tani-Sassa, Chihiro
    Yuasa, Sonoka
    Kanehira, Saki
    Sonobe, Kazunari
    Nukui, Yoko
    Takeuchi, Hiroaki
    Tanimoto, Kousuke
    Tanaka, Yukie
    Kimura, Akinori
    Ichimura, Naoya
    Tohda, Shuji
    IMMUNITY INFLAMMATION AND DISEASE, 2023, 11 (02)
  • [40] Estimated Effectiveness of Prior SARS-CoV-2 BA.1 or BA.2 Infection and Booster Vaccination Against Omicron BA.5 Subvariant Infection
    Jang, Eun Jung
    Choe, Young June
    Kim, Ryu Kyung
    Lee, Sangwon
    Park, Seon Kyeong
    Park, Young-Joon
    JAMA NETWORK OPEN, 2023, 6 (03) : E232578
12345