Monovalent vaccination with inactivated SARS-CoV-2 BA.5 protects hamsters against Omicron but not non-Omicron variants

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作者：
Chon Phin Ong
Kaiming Tang
Pak-Hin Hinson Cheung
Hongzhuo Zhang
Tze-Tung Tang
Yaqian Xue
Junjue Wang
Kelvin Kai-Wang To
Shuofeng Yuan
Zi-Wei Ye
Dong-Yan Jin
机构：
[1] The University of Hong Kong,School of Biomedical Sciences, Li Ka Shing Faculty of Medicine
[2] Pokfulam,State Key Laboratory of Emerging Infectious Diseases, Carol Yu Centre for Infection, Department of Microbiology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine
[3] The University of Hong Kong,Centre for Virology, Vaccinology and Therapeutics
[4] Pokfulam,Department of Infectious Disease and Microbiology
[5] Hong Kong Science and Technology Park,undefined
[6] Shatin,undefined
[7] The University of Hong Kong-Shenzhen Hospital,undefined
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npj Vaccines | / 8卷
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摘要：
We compared the protective effects of inactivated SARS-CoV-2 vaccines derived from the ancestral and the currently circulating BA.5.2 strains against infection with multiple variants in Syrian golden hamsters. Vaccination with BA.5.2 effectively protected against infection with the Omicron subvariants including XBB.1, but not the Alpha or Delta variant. In contrast, hamsters vaccinated with the ancestral strain demonstrated decent neutralization activity against both the Omicron and non-Omicron variants. Our findings might instruct future design and formulation of SARS-CoV-2 vaccines.
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