Monovalent vaccination with inactivated SARS-CoV-2 BA.5 protects hamsters against Omicron but not non-Omicron variants

被引:0
|
作者
Chon Phin Ong
Kaiming Tang
Pak-Hin Hinson Cheung
Hongzhuo Zhang
Tze-Tung Tang
Yaqian Xue
Junjue Wang
Kelvin Kai-Wang To
Shuofeng Yuan
Zi-Wei Ye
Dong-Yan Jin
机构
[1] The University of Hong Kong,School of Biomedical Sciences, Li Ka Shing Faculty of Medicine
[2] Pokfulam,State Key Laboratory of Emerging Infectious Diseases, Carol Yu Centre for Infection, Department of Microbiology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine
[3] The University of Hong Kong,Centre for Virology, Vaccinology and Therapeutics
[4] Pokfulam,Department of Infectious Disease and Microbiology
[5] Hong Kong Science and Technology Park,undefined
[6] Shatin,undefined
[7] The University of Hong Kong-Shenzhen Hospital,undefined
来源
关键词
D O I
暂无
中图分类号
学科分类号
摘要
We compared the protective effects of inactivated SARS-CoV-2 vaccines derived from the ancestral and the currently circulating BA.5.2 strains against infection with multiple variants in Syrian golden hamsters. Vaccination with BA.5.2 effectively protected against infection with the Omicron subvariants including XBB.1, but not the Alpha or Delta variant. In contrast, hamsters vaccinated with the ancestral strain demonstrated decent neutralization activity against both the Omicron and non-Omicron variants. Our findings might instruct future design and formulation of SARS-CoV-2 vaccines.
引用
收藏
相关论文
共 50 条
  • [1] Monovalent vaccination with inactivated SARS-CoV-2 BA.5 protects hamsters against Omicron but not non-Omicron variants
    Ong, Chon Phin
    Tang, Kaiming
    Cheung, Pak-Hin Hinson
    Zhang, Hongzhuo
    Tang, Tze-Tung
    Xue, Yaqian
    Wang, Junjue
    To, Kelvin Kai-Wang
    Yuan, Shuofeng
    Ye, Zi-Wei
    Jin, Dong-Yan
    NPJ VACCINES, 2023, 8 (01)
  • [2] Reinfection with SARS-CoV-2 Omicron BA.4 and BA.5 variants
    Nguyen, Nhu Ngoc
    Houhamdi, Linda
    Meddeb, Line
    Colson, Philippe
    Gautret, Philippe
    JOURNAL OF MEDICAL VIROLOGY, 2023, 95 (08)
  • [3] Vaccination with Omicron Inactivated Vaccine in Pre-vaccinated Mice Protects against SARS-CoV-2 Prototype and Omicron Variants
    Zhang, Yuntao
    Tan, Wenjie
    Lou, Zhiyong
    Zhao, Yuxiu
    Zhang, Jin
    Liang, Hongyang
    Li, Na
    Zhu, Xiujuan
    Ding, Ling
    Huang, Baoying
    Zhou, Weimin
    Guo, Yancen
    Yang, Zhaona
    Qiao, Yuling
    He, Zhenyu
    Ma, Bo
    He, Yao
    Zhu, Di
    Wang, Zhanhui
    Chang, Zhen
    Zhao, Xue
    Wang, Wei
    Xu, Ying
    Zhu, Huiqin
    Zheng, Xiaotong
    Wang, Chenlong
    Xu, Guangxue
    Wu, Guizhen
    Wang, Hui
    Yang, Xiaoming
    VACCINES, 2022, 10 (07)
  • [4] Transmission Characteristics and Inactivated Vaccine Effectiveness Against Transmission of SARS-CoV-2 Omicron BA.5 Variants in Urumqi, China
    Wang, Kai
    Guo, Zihao
    Zeng, Ting
    Sun, Shengzhi
    Lu, Yanmei
    Wang, Jun
    Li, Shulin
    Luan, Zemin
    Li, Huling
    Zhang, Jing
    Wang, Yida
    Lu, Yaoqin
    Zhao, Shi
    JAMA NETWORK OPEN, 2023, 6 (03) : E235755
  • [5] Neutralization against Omicron SARS-CoV-2 from previous non-Omicron infection
    Zou, Jing
    Xia, Hongjie
    Xie, Xuping
    Kurhade, Chaitanya
    Machado, Rafael R. G.
    Weaver, Scott C.
    Ren, Ping
    Shi, Pei-Yong
    NATURE COMMUNICATIONS, 2022, 13 (01)
  • [6] Neutralization against Omicron SARS-CoV-2 from previous non-Omicron infection
    Jing Zou
    Hongjie Xia
    Xuping Xie
    Chaitanya Kurhade
    Rafael R. G. Machado
    Scott C. Weaver
    Ping Ren
    Pei-Yong Shi
    Nature Communications, 13
  • [7] Reduced neutralization against Delta, Gamma, Mu, and Omicron BA.1 variants of SARS-CoV-2 from previous non-Omicron infection
    Paola Pidal
    Jorge Fernández
    Constanza Airola
    Miguel Araujo
    Ana María Menjiba
    Héctor San Martín
    Nicole Bruneau
    Monserrat Balanda
    Coral Elgueta
    Rodrigo Fasce
    María Teresa Valenzuela
    Ariel Orellana
    Eugenio Ramírez
    Medical Microbiology and Immunology, 2023, 212 : 25 - 34
  • [8] Immunogenicity and efficacy of vaccine boosters against SARS-CoV-2 Omicron subvariant BA.5 in male Syrian hamsters
    Machado, Rafael R. G.
    Walker, Jordyn L.
    Scharton, Dionna
    Rafael, Grace H.
    Mitchell, Brooke M.
    Reyna, Rachel A.
    de Souza, William M.
    Liu, Jianying
    Walker, David H.
    Plante, Jessica A.
    Plante, Kenneth S.
    Weaver, Scott C.
    NATURE COMMUNICATIONS, 2023, 14 (01)
  • [9] Immunogenicity and efficacy of vaccine boosters against SARS-CoV-2 Omicron subvariant BA.5 in male Syrian hamsters
    Rafael R. G. Machado
    Jordyn L. Walker
    Dionna Scharton
    Grace H. Rafael
    Brooke M. Mitchell
    Rachel A. Reyna
    William M. de Souza
    Jianying Liu
    David H. Walker
    Jessica A. Plante
    Kenneth S. Plante
    Scott C. Weaver
    Nature Communications, 14
  • [10] Novel SARS-CoV-2 Omicron variants in İstanbul; Rapid Preponderance of BA.2 and BA.5
    Tuyji-Tok, Yesim
    Yucebag, Ebru
    Keles, Ayse Betul
    Kilincarslan, Ayse Ceylan
    Nohut, Okan Kadir
    Salman-Yilmaz, Seda
    Kuskucu, Mert Ahmet
    Midilli, Kenan
    INFECTIOUS DISEASES AND CLINICAL MICROBIOLOGY, 2022, 4 (03): : 192 - 198