Reduced menin expression impairs rapamycin effects as evidenced by an increase in mTORC2 signaling and cell migration

被引：0
|
作者：
Masoud Razmara
Azita Monazzam
Britt Skogseid
机构：
[1] Uppsala University,Department of medical sciences, Science for Life Laboratory
来源：
Cell Communication and Signaling | / 16卷
关键词：
MEN1; PNET; PI3K; mTOR; Akt; Rapamycin;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
相关论文
共 50 条
  • [41] Lack of mTORC2 signaling in CD11c+ myeloid cells inhibits their migration and ameliorates experimental colitis
    Ignacio, Aline
    Cipelli, Marcella
    Takiishi, Tatiane
    Aguiar, Cristhiane Favero
    Fernandes Terra, Fernanda
    Ghirotto, Bruno
    Silva, Eloisa Martins
    Castoldi, Angela
    Magalhaes, Yuli Thamires
    Antonio, Tiago
    Padovani, Barbara Nunes
    Ioshie Hiyane, Meire
    Andrade-Oliveira, Vinicius
    Forti, Fabio Luis
    Camara, Niels Olsen Saraiva
    JOURNAL OF LEUKOCYTE BIOLOGY, 2024, 116 (04) : 779 - 792
  • [42] Superior cellular anti-tumor effects of a dual mTORC1/mTORC2 kinase inhibitor OXA-01 relative to the mTORC1 inhibitor rapamycin
    Bhagwat, Shripad
    Crew, Andrew
    Gokhale, Prafulla
    Yao, Yan
    Kahler, Jennifer
    Arnold, Lee
    Epstein, David
    Wild, Robert
    Pachter, Jonathan
    CANCER RESEARCH, 2009, 69
  • [43] Hepatic Sirt1 deficiency in mice impairs mTorc2/Akt signaling and results in hyperglycemia, oxidative damage, and insulin resistance
    Wang, Rui-Hong
    Kim, Hyun-Seok
    Xiao, Cuiying
    Xu, Xiaoling
    Gavrilova, Oksana
    Deng, Chu-Xia
    JOURNAL OF CLINICAL INVESTIGATION, 2011, 121 (11): : 4477 - 4490
  • [44] Activation of mammalian target of rapamycin complex 1 (mTORC1) and 2 (mTORC2) is required for retinal ganglion cell dendrite regeneration after axonal injury.
    Agostinone, Jessica
    Di Polo, Adriana
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2015, 56 (07)
  • [45] Vitamin D Deficiency Impairs mTORC2/Akt Signaling through Downregulating SIRT1 and Results in Increased Hepatic Gluconeogenesis
    Yuan, Qi
    Yang, Jinglei
    Sun, Mengyue
    Tang, Shan
    Dong, Meijuan
    Mao, Li
    DIABETES, 2020, 69
  • [46] Cardiac Stim1 Silencing Impairs Adaptive Hypertrophy and Promotes Heart Failure Through Inactivation of mTORC2/Akt Signaling
    Benard, Ludovic
    Oh, Jae Gyun
    Cacheux, Marine
    Lee, Ahyoung
    Nonnenmacher, Mathieu
    Matasic, Daniel S.
    Kohlbrenner, Erik
    Kho, Changwon
    Pavoine, Catherine
    Hajjar, Roger J.
    Hulot, Jean-Sebastien
    CIRCULATION, 2016, 133 (15) : 1458 - 1471
  • [47] Dendritic Cell Expression of Rictor (mTORC2), but Not Raptor (mTORC1), Protects Against Renal Ischemia-Reperfusion Injury
    Dai, H.
    Rogers, N.
    Watson, A.
    Fantus, D.
    Thomson, A.
    AMERICAN JOURNAL OF TRANSPLANTATION, 2017, 17 : 284 - 284
  • [48] mTORC2 controls T-cell receptor processing and surface expression during thymocyte development
    Werlen, Guy
    Chou, Po-Chien
    Oh, Won
    Wu, Chang-Chih
    Ruegg, Markus
    Hall, Michael
    Jacinto, Estela
    JOURNAL OF IMMUNOLOGY, 2012, 188
  • [49] Regulation of endothelial cell proliferation of infantile hemangioma through mTORC2 and FOXO1 signaling pathways
    Byun, J.
    Kim, H.
    Ahn, H.
    Park, H.
    Chung, H.
    JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2017, 137 (05) : S19 - S19
  • [50] Polycystin-1 regulates cell proliferation and migration through AKT/mTORC2 pathway in a human craniosynostosis cell model
    Katsianou, Maria A.
    Papavassiliou, Kostas A.
    Gargalionis, Antonios N.
    Agrogiannis, George
    Korkolopoulou, Penelope
    Panagopoulos, Dimitrios
    Themistocleous, Marios S.
    Piperi, Christina
    Basdra, Efthimia K.
    Papavassiliou, Athanasios G.
    JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2022, 26 (08) : 2428 - 2437
12345