Verticilide, a new ryanodine-binding inhibitor, produced by Verticillium sp. FKI-1033

被引：0

作者：

Kazuro Shiomi

Ryosuke Matsui

Atsuo Kakei

Yuichi Yamaguchi

Rokuro Masuma

Hiroko Hatano

Noriko Arai

Miki Isozaki

Haruo Tanaka

Susumu Kobayashi

Andreas Turberg

Satoshi Ōmura

机构：

[1] Kitasato Institute for Life Sciences and Graduate School of Infection Control Sciences,

[2] Kitasato University,undefined

[3] School of Pharmacy,undefined

[4] Kitasato University,undefined

[5] Faculty of Pharmaceutical Sciences,undefined

[6] Tokyo University of Science,undefined

[7] The Kitasato Institute,undefined

[8] Bayer Animal Health GmbH,undefined

[9] Research and Development,undefined

来源：

The Journal of Antibiotics | 2010年 / 63卷

关键词：

depsipeptide; insecticide; ryanodine-binding inhibitor; ryanodine receptor; verticilide;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

A new ryanodine-binding inhibitor, verticilide, was isolated from the cultured broth of a fungus, Verticillium sp. FKI-1033. It is a 24-membered ring cyclic depsipeptide, its structure being elucidated as cyclo[(2R)-2-hydroxyheptanoyl-N-methyl- L-alanyl]4. Verticilide inhibited ryanodine binding to ryanodine receptors in the cockroach at an IC50 value of 4.2 μM, whereas inhibition against mouse ryanodine receptors was weak (IC50=53.9 μM).

引用

页码：77 / 82

页数：5

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