Design, Synthesis and Antitumor Activity Evaluation of Trifluoromethyl-Containing Polysubstituted Pyrimidine Derivatives

被引:0
|
作者
C. Lingling
W. Hao
Y. Fuqiang
G. Chao
D. Honglin
S. Xiaojie
Z. Yang
Z. Jiaxin
S. Lihong
L. Hongmin
Z. Qiurong
机构
[1] School of Pharmaceutical Sciences,
[2] Zhengzhou University,undefined
[3] Collaborative Innovation Center of New Drug Research and Safety Evaluation,undefined
[4] State Key Laboratory of Esophageal Cancer Prevention and Treatment,undefined
[5] Key Laboratory of Advanced Drug Preparation Technologie,undefined
[6] Ministry of Education of China,undefined
关键词
pyrimidine derivatives; trifluoromethyl; synthesis; antiproliferative activity;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
页码:86 / 100
页数:14
相关论文
共 50 条
  • [21] Synthesis and Pharmacological Activity of Trifluoromethyl-Containing Imidazo[1,2-A]Benzimidazoles
    O. N. Zhukovskaya
    A. A. Spasov
    T. A. Kuz’menko
    A. S. Morkovnik
    A. F. Kucheryavenko
    V. A. Anisimova
    O. A. Salaznikova
    K. A. Gaidukova
    V. A. Kuznetsova
    D. A. Babkov
    O. Yu. Grechko
    N. V. Eliseeva
    A. I. Rashchenko
    Pharmaceutical Chemistry Journal, 2018, 52 : 385 - 391
  • [22] Synthesis and Pharmacological Activity of Trifluoromethyl-Containing Imidazo[1,2-A]Benzimidazoles
    Zhukovskaya, O. N.
    Spasov, A. A.
    Kuz'menko, T. A.
    Morkovnik, A. S.
    Kucheryavenko, A. F.
    Anisimova, V. A.
    Salaznikova, O. A.
    Gaidukova, K. A.
    Kuznetsova, V. A.
    Babkov, D. A.
    Grechko, O. Yu.
    Eliseeva, N. V.
    Rashchenko, A. I.
    PHARMACEUTICAL CHEMISTRY JOURNAL, 2018, 52 (05) : 385 - 391
  • [23] DESIGN, SYNTHESIS AND BIOLOGICAL EVALUATION OF PYRIMIDINE-BASED DERIVATIVES AS ANTITUMOR AGENTS
    Albratty, Mohammed M.
    El-Sharkawy, Karam A.
    Alhazmi, Hassan A.
    REVUE ROUMAINE DE CHIMIE, 2020, 65 (03) : 227 - 238
  • [24] Synthesis and Antitumor Activity Evaluation of Novel Hydrazone-Substituted Pyrimidine Derivatives
    Zhang, Yang
    Zhang, Luye
    Liu, Limin
    Wang, Tao
    Meng, Yaqi
    Li, Na
    Li, Erdong
    Wang, Zhengjie
    Liu, Xiujuan
    Zheng, Jiaxin
    Shan, Lihong
    Liu, Hongmin
    Zhang, Qiurong
    CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2020, 40 (06) : 1731 - 1736
  • [25] TRIFLUOROMETHYL-CONTAINING SULFANILAMIDES .1. SYNTHESIS AND IN-VITRO ANTIBACTERIAL ACTIVITY
    VIGORITA, MG
    OTTANA, R
    BISIGNANO, G
    FARMACO, 1994, 49 (03): : 197 - 200
  • [26] Synthesis and crystal structure of trifluoromethyl-containing bendamustine hydrochloride
    Yin, Yue
    Liu, Huailiang
    Xiao, Tangxin
    Sun, Xiaoqiang
    Yang, Ke
    Li, Zhengyi
    JOURNAL OF CHEMICAL RESEARCH, 2019, 43 (9-10) : 386 - 391
  • [27] Synthesis and Antitumor Activity of New Pyrimidine and Caffeine Derivatives
    Abu-Hashem, Ameen Ali
    Hussein, Hoda Abdel Raouf
    LETTERS IN DRUG DESIGN & DISCOVERY, 2015, 12 (06) : 471 - 478
  • [28] Synthesis of trifluoromethyl-containing heterocycles of pyrazoline and pyrazolidine series
    Nenaidenko, VG
    Sanin, AV
    Balenkova, ES
    ZHURNAL ORGANICHESKOI KHIMII, 1995, 31 (05): : 786 - 791
  • [29] Construction of trifluoromethyl-containing heterocycles from trifluoroacetimidoyl chlorides and derivatives
    Yang, Zuguang
    Wei, Guangming
    Chen, Zhengkai
    Wu, Xiao-Feng
    CHEMICAL COMMUNICATIONS, 2023, 59 (33) : 4872 - 4890
  • [30] Design, Synthesis, Molecular Modeling and Antitumor Evaluation of Novel Indolyl-Pyrimidine Derivatives with EGFR Inhibitory Activity
    Ahmed, Naglaa M.
    Youns, Mahmoud M.
    Soltan, Moustafa K.
    Said, Ahmed M.
    MOLECULES, 2021, 26 (07):