Bone-targeting exosome nanoparticles activate Keap1 / Nrf2 / GPX4 signaling pathway to induce ferroptosis in osteosarcoma cells

被引：0
|
作者：
Wenkai Chen
Zongguang Li
Naichun Yu
Linlin Zhang
Hongyu Li
Yongjie Chen
Fengqing Gong
Wenping Lin
Xu He
Siyuan Wang
Yue Wu
Guangrong Ji
机构：
[1] Xiamen University,Department of Orthopedic Surgery, Xiang’an Hospital of Xiamen University, School of Medicine
[2] Xiamen University,Fujian Provincial Key Laboratory of Organ and Tissue Regeneration, Xiamen Key Laboratory of Regeneration Medicine, Organ Transplantation Institute of Xiamen University, School of Medicine
[3] Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine,Department of Spine Surgery, Shenzhen Pingle Orthopedic Hospital
[4] Xiamen University,Department of Orthopedic Surgery, Zhongshan Hospital, School of Medicine
[5] Xiamen University,Department of Pathology, Zhongshan Hospital, School of Medicine
来源：
Journal of Nanobiotechnology | / 21卷
关键词：
Homologous targeting; Ferroptosis; Osteosarcoma; Chemotherapy; Nrf2;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
相关论文
共 50 条
  • [41] Luteolin alleviates sorafenib-induced ferroptosis of BRL-3A cells through modulation of the Nrf2/GPX4 signaling pathway
    Zhang, Bo-Wen
    Yang, Di
    Li, Jin-Tao
    Peng, Mei-Hao
    Liao, Jia-Qing
    Zhao, Qi
    Yang, Yi-Xi
    Lu, Qiu-Xia
    TRADITIONAL MEDICINE RESEARCH, 2024, 9 (10):
  • [42] Wogonin induces ferroptosis in pancreatic cancer cells by inhibiting the Nrf2/GPX4 axis
    Liu, Xing
    Peng, Xinhui
    Cen, Shuai
    Yang, Cuiting
    Ma, Zhijie
    Shi, Xinyuan
    FRONTIERS IN PHARMACOLOGY, 2023, 14
  • [43] MicroRNA-7 activates Nrf2 pathway by targeting Keap1 expression
    Kabaria, Sayan
    Choi, Doo Chul
    Chaudhuri, Amrita Datta
    Jain, Mohit Raja
    Li, Hong
    Junn, Eunsung
    FREE RADICAL BIOLOGY AND MEDICINE, 2015, 89 : 548 - 556
  • [44] Epigenetic Therapeutics Targeting NRF2/KEAP1 Signaling in Cancer Oxidative Stress
    Zhang, Shunhao
    Duan, Sining
    Xie, Zhuojun
    Bao, Wanlin
    Xu, Bo
    Yang, Wenbin
    Zhou, Lingyun
    FRONTIERS IN PHARMACOLOGY, 2022, 13
  • [45] Curdione inhibits ferroptosis in isoprenaline-induced myocardial infarction via regulating Keap1/Trx1/GPX4 signaling pathway
    Wang, Huihui
    Xie, Baoping
    Shi, Shuotao
    Zhang, Rong
    Liang, Qi
    Liu, Zhongqiu
    Cheng, Yuanyuan
    PHYTOTHERAPY RESEARCH, 2023, 37 (11) : 5328 - 5340
  • [46] Mesenchymal stromal cells reduce ferroptosis of podocytes by activating the Nrf2/HO-1/GPX4 pathway in lupus nephritis
    Liu, Chang
    Liu, Xuanqi
    Wang, Yujiao
    Yu, Honghong
    Li, Qi
    Zheng, Yuanyuan
    Fu, Yao
    Yao, Genhong
    Sun, Lingyun
    INTERNATIONAL IMMUNOPHARMACOLOGY, 2025, 153
  • [47] Xanthohumol ameliorates drug-induced hepatic ferroptosis via activating Nrf2/xCT/GPX4 signaling pathway
    Deng, Yanyan
    Chu, Xiayan
    Li, Qian
    Zhu, Guanghao
    Hu, Jing
    Sun, Jianming
    Zeng, Hairong
    Huang, Jian
    Ge, Guangbo
    PHYTOMEDICINE, 2024, 126
  • [48] Celastrol alleviated acute kidney injury by inhibition of ferroptosis through Nrf2/GPX4 pathway
    Pan, Minling
    Wang, Zhen
    Wang, Yiyi
    Jiang, Xianqin
    Fan, Yali
    Gong, Fanghua
    Sun, Yunpeng
    Wang, Dezhong
    BIOMEDICINE & PHARMACOTHERAPY, 2023, 166
  • [49] Regulation of redox processes in biological systems with the participation of the Keap1/Nrf2/ARE signaling pathway, biogenic selenium nanoparticles as Nrf2 activators
    Bityutsky, V. S.
    Tsekhmistrenko, S., I
    Tsekhmistrenko, O. S.
    Tymoshok, N. O.
    Spivak, M. Y.
    REGULATORY MECHANISMS IN BIOSYSTEMS, 2020, 11 (04) : 483 - 493
  • [50] DJ-1 upregulates the Nrf2/GPX4 signal pathway to inhibit trophoblast ferroptosis in the pathogenesis of preeclampsia
    Tingting Liao
    Xia Xu
    Xu Ye
    Jianying Yan
    Scientific Reports, 12
12345