Physiological significance of taurine and the taurine transporter in intestinal epithelial cells

被引：0
|
作者：
M. Shimizu
H. Satsu
机构：
[1] Department of Applied Biological Chemistry,
[2] Graduate School of Agricultural and Life Sciences,undefined
[3] The University of Tokyo,undefined
[4] Bunkyo-ku,undefined
[5] Tokyo,undefined
[6] Japan,undefined
来源：
Amino Acids | 2000年 / 19卷
关键词：
Keywords: Amino acids – Taurine – Transporter – Osmoregulation – Small intestine – Caco-2;
D O I：
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中图分类号：
学科分类号：
摘要：
Taurine transport in human intestinal epithelial Caco-2 cells was down-regulated by culturing the cells in taurine-containing media and was up-regulated in a taurine-free medium. This adaptive regulation was associated with changes in both the Vmax and Km values of taurine transport. A change in the mRNA level of the taurine transporter (TAUT) in this regulation was also observed. The presence of such a regulatory mechanism for maintaining the intracellular taurine content at a certain level suggests that taurine plays an important role in the intestinal cell functions. The intracellular taurine content was increased when Caco-2 cells were exposed to a hypertonic stress. TAUT was up-regulated via the increased expression of TAUT mRNA in the hypertonic cells, suggesting that taurine serves as an osmolyte and protects the cells from osmotic stress. Similar up-regulation of TAUT was observed in the small intestine of water-deprived rats.
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页码：605 / 614
页数：9
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