Synthesis of 6-Acyl-7-aryl-4,7-dihydrotetrazolo[1,5-a]pyrimidine-5-carboxylic acids and their methyl esters

被引：0
|
作者：
V. L. Gein
L. F. Gein
E. P. Tsyplyakova
O. S. Panova
机构：
[1] Perm State Pharmaceutical Academy,
[2] Perm State Medical Academy,undefined
来源：
Russian Journal of Organic Chemistry | 2007年 / 43卷
关键词：
Dihydro; Aromatic Aldehyde; Ylate; Acetic Acid Lead; Colored Crys;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
6-Acyl-7-aryl-4,7-dihydrotetrazolo[1,5-a]pyrimidine-5-carboxylic acids and methyl 6-acyl-7-aryl-4,7-dihydrotetrazolo[1,5-a]pyrimidine-5-carboxylates were synthesized by fusion of 4-aryl-2,4-dioxobutanoic acids and their methyl esters, respectively, with 1H-tetrazol-5-amine and aromatic aldehydes. The reaction of methyl 2,4-dioxopentanoate with 1H-tetrazol-5-amine and 2-fluorobenzaldehyde in boiling acetic acid gave methyl 6-acetyl-5-hydroxy-7-(2-fluorophenyl)-4,5,6,7-tetrahydrotetrazolo[1,5-a]pyrimidine-5-carboxylate.
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收藏
页码：1382 / 1386
页数：4
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