Differentiation of human and murine induced pluripotent stem cells to microglia-like cells

被引：0
|
作者：
Hetal Pandya
Michael J Shen
David M Ichikawa
Andrea B Sedlock
Yong Choi
Kory R Johnson
Gloria Kim
Mason A Brown
Abdel G Elkahloun
Dragan Maric
Colin L Sweeney
Selamawit Gossa
Harry L Malech
Dorian B McGavern
John K Park
机构：
[1] National Institute of Neurological Disorders and Stroke,
[2] National Institutes of Health,undefined
[3] National Human Genome Research Institute,undefined
[4] National Institutes of Health,undefined
[5] National Institute of Allergy and Infectious Diseases,undefined
[6] National Institutes of Health,undefined
[7] Santa Barbara Neuroscience Institute,undefined
来源：
Nature Neuroscience | 2017年 / 20卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Pandya et al. describe a protocol to differentiate human and mouse iPSCs into cells with the phenotype, transcriptional profile and functional properties of microglia. The treatment of murine intracranial malignant gliomas with these cells demonstrates their potential clinical use. These microglia-like cells will enable further studies into the role of microglia in health and disease.
引用
收藏
页码：753 / 759
页数：6
相关论文
共 50 条
  • [1] Differentiation of human and murine induced pluripotent stem cells to microglia-like cells
    Pandya, Hetal
    Shen, Michael J.
    Ichikawa, David M.
    Sedlock, Andrea B.
    Choi, Yong
    Johnson, Kory R.
    Kim, Gloria
    Brown, Mason A.
    Elkahloun, Abdel G.
    Maric, Dragan
    Sweeney, Colin L.
    Gossa, Selamawit
    Malech, Harry L.
    McGavern, Dorian B.
    Park, John K.
    NATURE NEUROSCIENCE, 2017, 20 (05) : 753 - +
  • [2] DIFFERENTIATION AND GENERATION OF MICROGLIA-LIKE CELLS FROM HUMAN INDUCED PLURIPOTENT STEM CELLS
    Pandya, Hetal
    Choi, Yong
    Park, John
    NEURO-ONCOLOGY, 2013, 15 : 71 - 71
  • [3] Generation of pure monocultures of human microglia-like cells from induced pluripotent stem cells
    Banerjee, Poulomi
    Paza, Evdokia
    Perkins, Emma M.
    James, Owen G.
    Kenkhuis, Boyd
    Lloyd, Amy F.
    Burr, Karen
    Story, David
    Yusuf, Dilmurat
    He, Xin
    Backofen, Rolf
    Dando, Owen
    Chandran, Siddharthan
    Priller, Josef
    STEM CELL RESEARCH, 2020, 49
  • [4] Efficient derivation of microglia-like cells from human pluripotent stem cells
    Julien Muffat
    Yun Li
    Bingbing Yuan
    Maisam Mitalipova
    Attya Omer
    Sean Corcoran
    Grisilda Bakiasi
    Li-Huei Tsai
    Patrick Aubourg
    Richard M Ransohoff
    Rudolf Jaenisch
    Nature Medicine, 2016, 22 : 1358 - 1367
  • [5] Efficient derivation of microglia-like cells from human pluripotent stem cells
    Muffat, Julien
    Yuan, Bingbing
    Mitalipoya, Maisam
    Omer, Attya
    Corcoran, Sean
    Bakiasi, Grisilda
    Tsai, Li-Huei
    Aubourg, Patrick
    Ransohoff, Richard M.
    Jaenisch, Rudolf
    NATURE MEDICINE, 2016, 22 (11) : 1358 - 1367
  • [6] Human Microglia-like Cells: Differentiation from Induced Pluripotent Stem Cells and In Vitro Live-cell Phagocytosis Assay using Human Synaptosomes
    Funes, Salome
    Bosco, Daryl A.
    JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, 2022, (186):
  • [7] Incorporating microglia-like cells in human induced pluripotent stem cell-derived retinal organoids
    Chichagova, Valeria
    Georgiou, Maria
    Carter, Madeleine
    Dorgau, Birthe
    Hilgen, Gerrit
    Collin, Joseph
    Queen, Rachel
    Chung, Git
    Ajeian, Jila
    Moya-Molina, Marina
    Kustermann, Stefan
    Pognan, Francois
    Hewitt, Philip
    Schmitt, Michael
    Sernagor, Evelyne
    Armstrong, Lyle
    Lako, Majlinda
    JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2023, 27 (03) : 435 - 445
  • [8] Induced pluripotent stem cells-derived human microglia-like cells to study pathological changes of Alzheimer disease
    XU Mei
    JIANG Ning
    ZHOU Wen-xia
    ZHANG Yong-xiang
    中国药理学与毒理学杂志, 2018, 32 (09) : 738 - 738
  • [9] Directed Differentiation of Human Pluripotent Stem Cells to Microglia
    Douvaras, Panagiotis
    Sun, Bruce
    Wang, Minghui
    Kruglikov, Ilya
    Lallos, Gregory
    Zimmer, Matthew
    Terrenoire, Cecile
    Zhang, Bin
    Gandy, Sam
    Schadt, Eric
    Freytes, Donald O.
    Noggle, Scott
    Fossati, Valentina
    STEM CELL REPORTS, 2017, 8 (06): : 1516 - 1524
  • [10] Differentiation of mouse bone marrow derived stem cells toward microglia-like cells
    Arnd Hinze
    Alexandra Stolzing
    BMC Cell Biology, 12
12345