Differentiation of human and murine induced pluripotent stem cells to microglia-like cells

被引：0
|
作者：
Hetal Pandya
Michael J Shen
David M Ichikawa
Andrea B Sedlock
Yong Choi
Kory R Johnson
Gloria Kim
Mason A Brown
Abdel G Elkahloun
Dragan Maric
Colin L Sweeney
Selamawit Gossa
Harry L Malech
Dorian B McGavern
John K Park
机构：
[1] National Institute of Neurological Disorders and Stroke,
[2] National Institutes of Health,undefined
[3] National Human Genome Research Institute,undefined
[4] National Institutes of Health,undefined
[5] National Institute of Allergy and Infectious Diseases,undefined
[6] National Institutes of Health,undefined
[7] Santa Barbara Neuroscience Institute,undefined
来源：
Nature Neuroscience | 2017年 / 20卷
关键词：
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学科分类号：
摘要：
Pandya et al. describe a protocol to differentiate human and mouse iPSCs into cells with the phenotype, transcriptional profile and functional properties of microglia. The treatment of murine intracranial malignant gliomas with these cells demonstrates their potential clinical use. These microglia-like cells will enable further studies into the role of microglia in health and disease.
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页码：753 / 759
页数：6
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