Continuous-flow catalytic hydrogenation of 3a,6-epoxyisoindoles

被引：0

作者：

V. P. Zaytsev

F. I. Zubkov

D. F. Mertsalov

D. N. Orlova

E. A. Sorokina

E. V. Nikitina

A. V. Varlamov

机构：

[1] People’s Friendship University of Russia,Deparment of Organic Chemistry

[2] Shared Research and Educational Center of Physico-Chemical Studies of New Materials,undefined

[3] Substances,undefined

[4] and Catalytic Systems”,undefined

来源：

Russian Chemical Bulletin | 2015年 / 64卷

关键词：

continuous-flow reactor; heterogeneous catalytic hydrogenation; reduction; 3a,6-epoxyisoindoles; deuteration;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Selective catalytic (10% Pd/C) hydrogenation of the double bond in the oxabicyclo[2.2.1]heptene fragment of substituted fused 1-oxo-3a,6-epoxyisoindoles is described. A continuous-flow hydrogenation device that incorporates in situ hydrogen generation by electrolysis of water was used. Changing the hydrogen source from water to deuterium oxide provides possibility to synthesize deuterated oxoepoxyisoindolones. Hydrogenation is stereoselective to give exclusively exo-cis deuterated derivatives.

引用

页码：112 / 126

页数：14

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