Neutrophil elastase in bronchiectasis

被引：0
|
作者：
Andrea Gramegna
Francesco Amati
Leonardo Terranova
Giovanni Sotgiu
Paolo Tarsia
Daniela Miglietta
Maria Adelaide Calderazzo
Stefano Aliberti
Francesco Blasi
机构：
[1] University of Milan,Department of Pathophysiology and Transplantation
[2] Internal Medicine Department,Department of Clinical Sciences and Community Health University of Milano, Paediatric Highly Intensive Care Unit
[3] Respiratory Unit and Cystic Fibrosis Adult Center,Department of Biomedical Sciences, Clinical Epidemiology and Medical Statistics Unit
[4] Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico,undefined
[5] Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico,undefined
[6] University of Sassari,undefined
[7] Corporate Pre-Clinical R&D,undefined
[8] Chiesi Farmaceutici SpA,undefined
[9] Global Clinical Development,undefined
[10] Chiesi Farmaceutici SpA,undefined
来源：
Respiratory Research | / 18卷
关键词：
Bronchiectasis; Neutrophil elastase; Protease; Neutrophil elastase inhibitors; Desmosine;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The role of neutrophil elastase (NE) is poorly understood in bronchiectasis because of the lack of preclinical data and so most of the assumptions made about NE inhibitor potential benefit is based on data from CF. In this context, NE seems to be a predictor of long-term clinical outcomes and a possible target of treatment. In order to better evaluate the role of NE in bronchiectasis, a systematic search of scientific evidence was performed.
引用
收藏
相关论文
共 50 条
  • [41] NEUTROPHIL ELASTASE IN ALCOHOLIC CIRRHOSIS
    ANTONSEN, S
    HAVELUND, T
    SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION, 1986, 46 : 144 - 144
  • [42] Neutrophil elastase unleashed - Comment
    Horwitz, M
    BLOOD, 2005, 105 (09) : 3392 - 3393
  • [43] Inhibitors of human neutrophil elastase
    Edwards, PD
    Veale, CA
    EXPERT OPINION ON THERAPEUTIC PATENTS, 1997, 7 (01) : 17 - 28
  • [44] CRYSTALLIZATION OF HUMAN NEUTROPHIL ELASTASE
    WILLIAMS, HR
    LIN, TY
    NAVIA, MA
    SPRINGER, JP
    MCKEEVER, BM
    HOOGSTEEN, K
    DORN, CP
    FEDERATION PROCEEDINGS, 1987, 46 (06) : 1963 - 1963
  • [45] Inhibition of intracellular neutrophil elastase
    不详
    DRUG DISCOVERY TODAY, 2001, 6 (14) : 745 - 745
  • [46] Neutrophil elastase and trastuzumab responsiveness
    Harao, Michiko
    Sato, Takashi
    Fukutomi, Takashi
    Yorozuya, Kyoko
    Takasugi, Miyuki
    Mohri, Yukako
    Mizumoto, Takao
    Takahashi, Satoshi
    Yamashita, Jun-ichi
    ONKOLOGIE, 2007, 30 (11): : 583 - 584
  • [47] Neutrophil elastase and acute lung injury: Prospects for sivelestat and other neutrophil elastase inhibitors as therapeutics
    Zeiher, BG
    Matsuoka, S
    Kawabata, K
    Repine, JE
    CRITICAL CARE MEDICINE, 2002, 30 (05) : S281 - S287
  • [48] Neutrophil Elastase and Neutrophil Extracellular Traps in the Tumor Microenvironment
    Huang, Hai
    Zhang, Hongji
    Onuma, Amblessed E.
    Tsung, Allan
    TUMOR MICROENVIRONMENT: STATE OF THE SCIENCE, 2020, 1263 : 13 - 23
  • [49] Oxidative Modification of Neutrophil Elastase Causes a Loss of Elastase Activity
    Karren, E. A.
    Adair-Kirk, T. L.
    Senior, R. M.
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2009, 179
  • [50] Colistin stimulates the activity of neutrophil elastase and Pseudomonas aeruginosa elastase
    Jones, A
    Elphick, H
    Pettit, E
    Everard, ML
    Evans, GS
    EUROPEAN RESPIRATORY JOURNAL, 2002, 19 (06) : 1136 - 1141
12345