Neutrophil elastase in bronchiectasis

被引：0

作者：

Andrea Gramegna

Francesco Amati

Leonardo Terranova

Giovanni Sotgiu

Paolo Tarsia

Daniela Miglietta

Maria Adelaide Calderazzo

Stefano Aliberti

Francesco Blasi

机构：

[1] University of Milan,Department of Pathophysiology and Transplantation

[2] Internal Medicine Department,Department of Clinical Sciences and Community Health University of Milano, Paediatric Highly Intensive Care Unit

[3] Respiratory Unit and Cystic Fibrosis Adult Center,Department of Biomedical Sciences, Clinical Epidemiology and Medical Statistics Unit

[4] Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico,undefined

[5] Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico,undefined

[6] University of Sassari,undefined

[7] Corporate Pre-Clinical R&D,undefined

[8] Chiesi Farmaceutici SpA,undefined

[9] Global Clinical Development,undefined

[10] Chiesi Farmaceutici SpA,undefined

来源：

Respiratory Research | / 18卷

关键词：

Bronchiectasis; Neutrophil elastase; Protease; Neutrophil elastase inhibitors; Desmosine;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

The role of neutrophil elastase (NE) is poorly understood in bronchiectasis because of the lack of preclinical data and so most of the assumptions made about NE inhibitor potential benefit is based on data from CF. In this context, NE seems to be a predictor of long-term clinical outcomes and a possible target of treatment. In order to better evaluate the role of NE in bronchiectasis, a systematic search of scientific evidence was performed.

引用

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