Noopept pharmacokinetics after intravenous administration of a lyophilized medicinal form in rats

被引：0
|
作者：
Boiko S.S. [1 ]
Zherdev V.P. [1 ]
Kolyvanov V.P. [1 ]
Ostrovskaya R.U. [1 ]
Gudasheva T.A. [1 ]
Us K.S. [1 ]
Seredenin S.B. [1 ]
机构：
[1] Zakusov Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow
来源：
Pharmaceutical Chemistry Journal | 2007年 / 41卷 / 3期
基金：
俄罗斯基础研究基金会;
关键词：
Mannitol; Blood Plasma; Parent Substance; Typical Chromatogram; White Mongrel;
D O I：
10.1007/s11094-007-0027-0
中图分类号：
学科分类号：
摘要：
The pharmacokinetics of noopept, a dipeptide drug possessing nootropic and neuroprotective properties, were evaluated in rats after the intravenous administration of its novel formulation for injections prepared using lyophilization in the presence of mannitol. The pharmacokinetic characteristics of the new preparation are comparable with those of aqueous solutions of the parent substance and can be recommended for further investigation and implementation into medical practice. © 2007 Springer Science+Business Media, Inc.
引用
收藏
页码：123 / 125
页数：2
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