Noopept pharmacokinetics after intravenous administration of a lyophilized medicinal form in rats

被引：0
|
作者：
Boiko S.S. [1 ]
Zherdev V.P. [1 ]
Kolyvanov V.P. [1 ]
Ostrovskaya R.U. [1 ]
Gudasheva T.A. [1 ]
Us K.S. [1 ]
Seredenin S.B. [1 ]
机构：
[1] Zakusov Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow
来源：
Pharmaceutical Chemistry Journal | 2007年 / 41卷 / 3期
基金：
俄罗斯基础研究基金会;
关键词：
Mannitol; Blood Plasma; Parent Substance; Typical Chromatogram; White Mongrel;
D O I：
10.1007/s11094-007-0027-0
中图分类号：
学科分类号：
摘要：
The pharmacokinetics of noopept, a dipeptide drug possessing nootropic and neuroprotective properties, were evaluated in rats after the intravenous administration of its novel formulation for injections prepared using lyophilization in the presence of mannitol. The pharmacokinetic characteristics of the new preparation are comparable with those of aqueous solutions of the parent substance and can be recommended for further investigation and implementation into medical practice. © 2007 Springer Science+Business Media, Inc.
引用
收藏
页码：123 / 125
页数：2
相关论文
共 50 条
  • [21] Pharmacokinetics of felbinac after intravenous administration of felbinac trometamol in rats
    Zhang, Chao
    Gu, Jingkai
    DRUG METABOLISM REVIEWS, 2011, 43 : 73 - 74
  • [22] Effects of dexamethasone on the pharmacokinetics of adriamycin after intravenous administration to rats
    Lee, HJ
    Lee, MG
    RESEARCH COMMUNICATIONS IN MOLECULAR PATHOLOGY AND PHARMACOLOGY, 1999, 105 (1-2) : 87 - 96
  • [23] Nonlinear pharmacokinetics of visnagin in rats after intravenous bolus administration
    Haug, Karin G.
    Weber, Benjamin
    Hochhaus, Guenther
    Butterweck, Veronika
    EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2012, 45 (1-2) : 79 - 89
  • [24] Effects of Glipizide on the Pharmacokinetics of Carvedilol after Oral and Intravenous Administration in Rats
    Lee, Chong-Ki
    Choi, Jun-Shik
    BIOMOLECULES & THERAPEUTICS, 2011, 19 (02) : 237 - 242
  • [25] Effects of verapamil on etoposide pharmacokinetics after intravenous and oral administration in rats
    Piao Y.-J.
    Li X.
    Choi J.-S.
    European Journal of Drug Metabolism and Pharmacokinetics, 2008, 33 (3) : 159 - 164
  • [26] Effects of Cilostazol on the Pharmacokinetics of Nifedipine After Oral and Intravenous Administration in Rats
    Chong-Ki Lee
    Jun-Shik Choi
    Dong-Hyun Choi
    Pharmaceutical Chemistry Journal, 2017, 51 : 748 - 755
  • [27] Mephedrone pharmacokinetics after intravenous and oral administration in rats: relation to pharmacodynamics
    J. Martínez-Clemente
    R. López-Arnau
    M. Carbó
    D. Pubill
    J. Camarasa
    E. Escubedo
    Psychopharmacology, 2013, 229 : 295 - 306
  • [28] Cocaine pharmacodynamics after intravenous and oral administration in rats: relation to pharmacokinetics
    Fang Ma
    John L. Falk
    C. E. Lau
    Psychopharmacology, 1999, 144 : 323 - 332
  • [29] PHARMACOKINETICS OF PROGESTERONE IN OVARIECTOMIZED RATS AFTER SINGLE DOSE INTRAVENOUS ADMINISTRATION
    GANGRADE, NK
    BOUDINOT, FD
    PRICE, JC
    BIOPHARMACEUTICS & DRUG DISPOSITION, 1992, 13 (09) : 703 - 709
  • [30] Effects of Atorvastatin on the Pharmacokinetics of Nicardipine after Oral and Intravenous Administration in Rats
    Choi, Jun-Shik
    Ha, Sung-Il
    Choi, Dong-Hyun
    BIOMOLECULES & THERAPEUTICS, 2010, 18 (02) : 226 - 232
12345