Cytotoxic and regulatory roles of mucosal-associated invariant T cells in type 1 diabetes

被引：0

作者：

Ophélie Rouxel

Jennifer Da silva

Lucie Beaudoin

Isabelle Nel

Céline Tard

Lucie Cagninacci

Badr Kiaf

Masaya Oshima

Marc Diedisheim

Marion Salou

Alexandra Corbett

Jamie Rossjohn

James McCluskey

Raphael Scharfmann

Manuela Battaglia

Michel Polak

Olivier Lantz

Jacques Beltrand

Agnès Lehuen

机构：

[1] INSERM U1016,Infection and Immunity Program and Department of Biochemistry and Molecular Biology

[2] Institut Cochin,Department of Microbiology and Immunology

[3] Paris,undefined

[4] France,undefined

[5] and Université Paris Descartes,undefined

[6] CNRS,undefined

[7] UMR8104,undefined

[8] Laboratoire d'Excellence INFLAMEX,undefined

[9] Sorbonne Paris Cité,undefined

[10] ,undefined

[11] INSERM U932,undefined

[12] Institut Curie,undefined

[13] Biomedicine Discovery Institute,undefined

[14] Monash University,undefined

[15] ARC Centre of Excellence in Advanced Molecular Imaging,undefined

[16] Monash University,undefined

[17] Institute of Infection and Immunity,undefined

[18] Cardiff University,undefined

[19] Peter Doherty Institute for Infection and Immunity,undefined

[20] University of Melbourne,undefined

[21] Diabetes Research Institute,undefined

[22] IRCCS San Raffaele Scientific Institute,undefined

[23] Milan,undefined

[24] Italy,undefined

[25] and TrialNet Clinical Center,undefined

[26] San Raffaele Hospital,undefined

[27] Service Endocrinologie,undefined

[28] Gynécologie et Diabétologie Pédiatrique,undefined

[29] Hôpital Universitaire Necker Enfants Malades,undefined

[30] Assistance Publique-Hôpitaux de Paris,undefined

[31] Faculté de Médecine Paris Descartes,undefined

[32] Université Sorbonne Paris Cité,undefined

来源：

Nature Immunology | 2017年 / 18卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Type 1 diabetes has a multifactorial etiology. Lehuen and colleagues demonstrate that MAIT cells serve both positive roles and negative roles in type 1 diabetes by maintaining gut integrity and limiting pancreatic inflammation but also directly destroying β-cells.

引用

页码：1321 / 1331

页数：10

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