Assessment of TANK-binding kinase 1 as a therapeutic target in cancer

被引：0

作者：

Victoria H. Cruz

Rolf A. Brekken

机构：

[1] UT Southwestern Medical Center,Cancer Biology Graduate Program, Hamon Center for Therapeutic Oncology Research and Department of Surgery

[2] UT Southwestern Medical Center,Department of Pharmacology

来源：

Journal of Cell Communication and Signaling | 2018年 / 12卷

关键词：

Autophagy; Cancer therapeutic target; Pancreatic cancer; RAS; TBK1;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

TANK-binding kinase 1 (TBK1) is central to multiple biological processes that promote tumorigenesis including cell division, autophagy, innate immune response and AKT-pro survival signaling. TBK1 is well studied and most known for its function in innate immunity. However, the serine threonine protein kinase received significant attention as a synthetic lethal partner and effector of the major oncogene, RAS. This review summarizes newly identified cancer promoting functions of TBK1 and evaluates the therapeutic potential of targeting TBK1 in cancer.

引用

页码：83 / 90

页数：7

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