Assessment of TANK-binding kinase 1 as a therapeutic target in cancer

被引：0
|
作者：
Victoria H. Cruz
Rolf A. Brekken
机构：
[1] UT Southwestern Medical Center,Cancer Biology Graduate Program, Hamon Center for Therapeutic Oncology Research and Department of Surgery
[2] UT Southwestern Medical Center,Department of Pharmacology
来源：
Journal of Cell Communication and Signaling | 2018年 / 12卷
关键词：
Autophagy; Cancer therapeutic target; Pancreatic cancer; RAS; TBK1;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
TANK-binding kinase 1 (TBK1) is central to multiple biological processes that promote tumorigenesis including cell division, autophagy, innate immune response and AKT-pro survival signaling. TBK1 is well studied and most known for its function in innate immunity. However, the serine threonine protein kinase received significant attention as a synthetic lethal partner and effector of the major oncogene, RAS. This review summarizes newly identified cancer promoting functions of TBK1 and evaluates the therapeutic potential of targeting TBK1 in cancer.
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页码：83 / 90
页数：7
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