An RNAi screen of Rho signalling networks identifies RhoH as a regulator of Rac1 in prostate cancer cell migration

被引：0
|
作者：
Virginia Tajadura-Ortega
Ritu Garg
Richard Allen
Claudia Owczarek
Michael D. Bright
Samuel Kean
Aisyah Mohd-Noor
Anita Grigoriadis
Timothy C. Elston
Klaus M. Hahn
Anne J. Ridley
机构：
[1] King’s College London,Randall Centre of Cell and Molecular Biophysics
[2] King’s College London,School of Cardiovascular Medicine and Sciences
[3] University of North Carolina at Chapel Hill,Department of Pharmacology
[4] King’s College London,School of Cancer and Pharmaceutical Sciences
[5] Guy’s Hospital,School of Cellular and Molecular Medicine
[6] University of Bristol,Present address: Internal Medicine Research Unit
[7] Pfizer Inc,undefined
[8] Present address: Institute for Cancer Research,undefined
来源：
BMC Biology | / 16卷
关键词：
RNAi Screen; Epithelial Cancer Cell Lines; Polish Migrants; siRNA Pool; Increased Spreading Area;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
相关论文
共 50 条
  • [41] PTHrP promotes colon cancer cell migration and invasion in an integrin α6β4-dependent manner through activation of Rac1
    Mula, Ramanjaneya V.
    Bhatia, Vandanajay
    Falzon, Miriam
    CANCER LETTERS, 2010, 298 (01) : 119 - 127
  • [42] NEDD9 Facilitates Hypoxia-Induced Gastric Cancer Cell Migration via MICAL1 Related Rac1 Activation
    Zhao, Shuo
    Min, Pengxiang
    Liu, Lei
    Zhang, Lin
    Zhang, Yujie
    Wang, Yueyuan
    Zhao, Xuyang
    Ma, Yadong
    Xie, Hui
    Zhu, Chenchen
    Jiang, Haonan
    Du, Jun
    Gu, Luo
    FRONTIERS IN PHARMACOLOGY, 2019, 10
  • [43] Single-Cell Transcriptomics Analysis Identifies Nuclear Protein 1 as a Regulator of Docetaxel Resistance in Prostate Cancer Cells
    Schnepp, Patricia M.
    Shelley, Greg
    Dai, Jinlu
    Wakim, Nicole
    Jiang, Hui
    Mizokami, Atsushi
    Keller, Evan T.
    MOLECULAR CANCER RESEARCH, 2020, 18 (09) : 1290 - 1301
  • [44] The PIM1 kinase promotes prostate cancer cell migration and adhesion via multiple signalling pathways
    Santio, Niina M.
    Salmela, Maria
    Arola, Heidi
    Eerola, Sini K.
    Heino, Jyrki
    Rainio, Eeva-Marja
    Koskinen, Paivi J.
    EXPERIMENTAL CELL RESEARCH, 2016, 342 (02) : 113 - 124
  • [45] Icariin exterts negative effects on human gastric cancer cell invasion and migration by vasodilator-stimulated phosphoprotein via Rac1 pathway
    Wang, Yongping
    Dong, Huimin
    Zhu, Meng
    Ou, Yangwen
    Zhang, Jie
    Luo, Hesheng
    Luo, Ruoyu
    Wu, Junzhu
    Mao, Ming
    Liu, Xiaoheng
    Zhang, Jingwei
    Wei, Lei
    EUROPEAN JOURNAL OF PHARMACOLOGY, 2010, 635 (1-3) : 40 - 48
  • [46] PIKfyve, MTMR3 and their product PtdIns5P regulate cancer cell migration and invasion through activation of Rac1
    Oppelt, Angela
    Haugsten, Ellen M.
    Zech, Tobias
    Danielsen, Havard E.
    Sveen, Anita
    Lobert, Viola H.
    Skotheim, Rolf I.
    Wesche, Jorgen
    BIOCHEMICAL JOURNAL, 2014, 461 : 383 - 390
  • [47] Deregulation of the Rho GTPase, Rac1, suppresses cyclin-dependent kinase inhibitor p21CIP1 levels in androgen-independent human prostate cancer cells
    Knight-Krajewski, S
    Welsh, CF
    Liu, YQ
    Lyons, LS
    Faysal, JM
    Yang, ES
    Burnstein, KL
    ONCOGENE, 2004, 23 (32) : 5513 - 5522
  • [48] Deregulation of the Rho GTPase, Rac1, suppresses cyclin-dependent kinase inhibitor p21CIP1 levels in androgen-independent human prostate cancer cells
    Selena Knight-Krajewski
    Catherine F Welsh
    YunQi Liu
    Leah S Lyons
    Joanne M Faysal
    Eddy S Yang
    Kerry L Burnstein
    Oncogene, 2004, 23 : 5513 - 5522
  • [49] NEK2 Phosphorylates RhoGDI1 to Promote Cell Proliferation, Migration and Invasion Through the Activation of RhoA and Rac1 in Colon Cancer Cells
    Lim, Jeewon
    Hwang, Yo-Sep
    Kim, Jong-Tae
    Yoon, Hyang-Ran
    Park, Hyo-Min
    Han, Jahyeong
    Kwon, Taeho
    Lee, Kyung-Ho
    Cho, Hee-Jun
    Lee, Hee-Gu
    CELLS, 2024, 13 (24)
  • [50] RETRACTION: A novel interaction between the SH2 domain of signaling adaptor protein Nck-1 and the upstream regulator of the Rho family GTPase Rac1 engulfment and cell motility 1 (ELMO1) promotes Rac1 activation and cell motility (vol 289, pg 23112, 2014) (Retraction of Vol 289, Pg 23112, 2014)
    Zhang, Guo
    Chen, Xia
    Qiu, Fanghua
    Zhu, Fengxin
    Lei, Wenjing
    Nie, Jing
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2019, 294 (52) : 20262 - 20262
12345