An RNAi screen of Rho signalling networks identifies RhoH as a regulator of Rac1 in prostate cancer cell migration

被引:0
|
作者
Virginia Tajadura-Ortega
Ritu Garg
Richard Allen
Claudia Owczarek
Michael D. Bright
Samuel Kean
Aisyah Mohd-Noor
Anita Grigoriadis
Timothy C. Elston
Klaus M. Hahn
Anne J. Ridley
机构
[1] King’s College London,Randall Centre of Cell and Molecular Biophysics
[2] King’s College London,School of Cardiovascular Medicine and Sciences
[3] University of North Carolina at Chapel Hill,Department of Pharmacology
[4] King’s College London,School of Cancer and Pharmaceutical Sciences
[5] Guy’s Hospital,School of Cellular and Molecular Medicine
[6] University of Bristol,Present address: Internal Medicine Research Unit
[7] Pfizer Inc,undefined
[8] Present address: Institute for Cancer Research,undefined
来源
BMC Biology | / 16卷
关键词
RNAi Screen; Epithelial Cancer Cell Lines; Polish Migrants; siRNA Pool; Increased Spreading Area;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
相关论文
共 50 条
  • [21] Isoalvaxanthone inhibits colon cancer cell proliferation, migration and invasion through inactivating Rac1 and AP-1
    Wang, Lei
    Kuang, Lisha
    Pan, Xinhua
    Liu, Junchen
    Wang, Qian
    Du, Bing
    Li, Dali
    Luo, Jian
    Liu, Mingyao
    Hou, Aijun
    Qian, Min
    INTERNATIONAL JOURNAL OF CANCER, 2010, 127 (05) : 1220 - 1229
  • [22] Elmo1 Helps Dock180 to Regulate Rac1 Activity and Cell Migration of Ovarian Cancer
    Wang, Jin
    Dai, Jie-min
    Che, Ya-ling
    Gao, Yi-meng
    Peng, Hui-juan
    Liu, Bin
    Wang, Hui
    Hua Linghu
    INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, 2014, 24 (05) : 844 - 850
  • [23] Rac1 Activation Driven by 14-3-3ζ Dimerization Promotes Prostate Cancer Cell-Matrix Interactions, Motility and Transendothelial Migration
    Goc, Anna
    Abdalla, Maha
    Al-Azayzih, Ahmad
    Somanath, Payaningal R.
    PLOS ONE, 2012, 7 (07):
  • [24] Inhibition of cell proliferation and migration by Oroxylum indicum extracts on breast cancer cells via Rac1 modulation
    Benjaporn Buranrat
    Sirintra Noiwetch
    Tippaporn Suksar
    Aphimook Ta-ut
    Journal of Pharmaceutical Analysis, 2020, 10 (02) : 187 - 193
  • [25] Inhibition of cell proliferation and migration by Oroxylum indicum extracts on breast cancer cells via Rac1 modulation
    Buranrat, Benjaporn
    Noiwetch, Sirintra
    Suksar, Tippaporn
    Ta-ut, Aphimook
    JOURNAL OF PHARMACEUTICAL ANALYSIS, 2020, 10 (02) : 187 - 193
  • [26] MicroRNA-142-3p SUPPRESSES CELL PROLIFERATION AND MIGRATION IN BLADDER CANCER VIA Rac1
    Li, W. Q.
    Zhao, W. C.
    Xin, J.
    Niu, T. L.
    Chao, Y. F.
    Zhou, P.
    Zheng, M. H.
    Xu, B.
    JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS, 2020, 34 (01): : 83 - 92
  • [27] Tumor cell migration screen identifies SRPK1 as breast cancer metastasis determinant
    van Roosmalen, Wies
    Le Devedec, Sylvia E.
    Golani, Ofra
    Smid, Marcel
    Pulyakhina, Irina
    Timmermans, Annemieke M.
    Look, Maxime P.
    Zi, Di
    Pont, Chantal
    de Graauw, Marjo
    Naffar-Abu-Amara, Suha
    Kirsanova, Catherine
    Rustici, Gabriella
    't Hoen, Peter A. C.
    Martens, John W. M.
    Foekens, John A.
    Geiger, Benjamin
    van de Water, Bob
    JOURNAL OF CLINICAL INVESTIGATION, 2015, 125 (04): : 1648 - 1664
  • [28] Silibinin Inhibit Cell Migration through Downregulation of RAC1 Gene Expression in Highly Metastatic Breast Cancer Cell Line
    Lashgarian, Hamed Esmaeil
    Adamii, Vahid
    Ghorbanzadeh, Vajihe
    Chodari, Leila
    Kamali, Fayze
    Akbari, Soheila
    Dariushnejad, Hassan
    DRUG RESEARCH, 2020, 70 (10) : 478 - 483
  • [29] An unbiased seed-based RNAi selection screen identifies small RNAs that inhibit androgen signaling and prostate cancer cell growth
    Corbin, Joshua M.
    Georgescu, Constantin
    Wang, Lin
    Wren, Jonathan D.
    Bieniasz, Magdalena
    Xu, Chao
    Asch, Adam S.
    Echevarria, Maria J. Ruiz
    MOLECULAR THERAPY NUCLEIC ACIDS, 2023, 33 : 257 - 272
  • [30] PED Interacts With Rac1 and Regulates Cell Migration/Invasion Processes in Human Non-Small Cell Lung Cancer Cells
    Zanca, Ciro
    Cozzolin, Flora
    Quintavalle, Cristina
    Di Costanzo, Stefania
    Ricci-Vitiani, Lucia
    Santoriell, Margherita
    Monti, Maria
    Pucci, Piero
    Condorelli, Gerolama
    JOURNAL OF CELLULAR PHYSIOLOGY, 2010, 225 (01) : 63 - 72