Mechanisms of drug resistance mediated by long non-coding RNAs in non-small-cell lung cancer

被引：0
|
作者：
Manuela La Montagna
Lucy Ginn
Michela Garofalo
机构：
[1] University of Manchester,Transcriptional Networks in Lung Cancer Group, Cancer Research UK Manchester Institute
[2] Alderley Park,undefined
[3] Cancer Research UK Lung Cancer Centre of Excellence at Manchester and University College London,undefined
来源：
Cancer Gene Therapy | 2021年 / 28卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Non-small-cell lung cancer (NSCLC) is the most prevalent form of lung cancer and has a poor five-year survival rate of 15%. Chemotherapy and targeted therapies have significantly improved patients’ prognosis. Nevertheless, after a successful initial response, some patients relapse when cancer cells become resistant to drug treatments, representing an important clinical limitation. Therefore, investigating the mechanisms of drug resistance is of significant importance. Recently, considerable attention has been given to long non-coding RNAs (lncRNAs), a heterogeneous class of regulatory molecules that play essential roles in tumorigenesis by modulating genes and signalling pathways involved in cell growth, metastasis and drug response. In this article, we review recent research findings on the role of lncRNAs in drug resistance in NSCLC, highlighting their mechanisms of action.
引用
收藏
页码：175 / 187
页数：12
相关论文
共 50 条
  • [41] Anti-angiogenic Drug Resistance: Roles and Targeting of Non-coding RNAs (microRNAs and long non-coding RNAs)
    Dashtaki, Masoumeh Eliyasi
    Ghasemi, Sorayya
    CURRENT MOLECULAR PHARMACOLOGY, 2023, 16 (08) : 855 - 869
  • [42] Non-coding RNAs and exosomal non-coding RNAs in lung cancer: insights into their functions
    Lv, Xiaolong
    Yang, Lei
    Xie, Yunbo
    Momeni, Mohammad Reza
    FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2024, 12
  • [43] The role of selected non-coding RNAs in the biology of non-small cell lung cancer
    Kie, Kajetan
    Ptaszynski, Konrad
    Wojcik, Janusz
    Wojtys, MaIgorzata Edyta
    ADVANCES IN MEDICAL SCIENCES, 2023, 68 (01): : 121 - 137
  • [44] Long non-coding RNAs in cancer
    ZhaoJian Gong
    ShanShan Zhang
    WenLing Zhang
    HongBin Huang
    Qiao Li
    Hao Deng
    Jian Ma
    Ming Zhou
    JuanJuan Xiang
    MingHua Wu
    XiaYu Li
    Wei Xiong
    XiaoLing Li
    Yong Li
    ZhaoYang Zeng
    GuiYuan Li
    Science China Life Sciences, 2012, 55 : 1120 - 1124
  • [45] Long non-coding RNAs in cancer
    Gong ZhaoJian
    Zhang ShanShan
    Zhang WenLing
    Huang HongBin
    Li Qiao
    Deng Hao
    Ma Jian
    Zhou Ming
    Xiang JuanJuan
    Wu MingHua
    Li XiaYu
    Xiong Wei
    Li XiaoLing
    Li Yong
    Zeng ZhaoYang
    Li GuiYuan
    SCIENCE CHINA-LIFE SCIENCES, 2012, 55 (12) : 1120 - 1124
  • [46] Long non-coding RNAs in cancer
    Kim, Mi-Young
    NON-CODING RNA RESEARCH, 2019, 4 (02): : 45 - 45
  • [47] Long non-coding RNAs in cancer
    GONG ZhaoJian 1
    2 Key Laboratory of Carcinogenesis of Ministry of Health
    3 Department of Stomatology
    4 Department of Stomatology
    5 Key Laboratory of Information System Engineering
    6 Department of Biochemistry and Molecular Biology
    Science China(Life Sciences), 2012, (12) : 1120 - 1124
  • [48] Long non-coding RNAs in cancer
    GONG ZhaoJian ZHANG ShanShan ZHANG WenLing HUANG HongBin LI Qiao DENG Hao MA Jian ZHOU Ming XIANG JuanJuan WU MingHua LI XiaYu XIONG Wei LI XiaoLing LI Yong ZENG ZhaoYang LI GuiYuan Hunan Key Laboratory of Nonresolving Inflammation and Cancer Disease Genome Research Center the Third Xiangya Hospital Central South University Changsha China Key Laboratory of Carcinogenesis of Ministry of Health Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education Cancer Research Institute Central South University Changsha China Department of Stomatology the Second Xiangya Hospital Central South University Changsha China Department of Stomatology Xiangya Hospital Central South University Changsha China Key Laboratory of Information System Engineering National University of Defense Technology Changsha China Department of Biochemistry and Molecular Biology Center for Genetics and Molecular Medicine School of Medicine University of Louisville Louisville KY USA
    Science China(Life Sciences), 2012, 55 (12) : 1120 - 1124
  • [49] Roles, Functions, and Mechanisms of Long Non-coding RNAs in Cancer
    Yiwen Fang
    Melissa J.Fullwood
    Genomics,Proteomics & Bioinformatics, 2016, 14 (01) : 42 - 54
  • [50] Non-coding RNAs as Novel Biomarkers in Cancer Drug Resistance
    Yang, Haixiu
    Qi, Changlu
    Li, Boyan
    Cheng, Liang
    CURRENT MEDICINAL CHEMISTRY, 2022, 29 (05) : 837 - 848
12345