Roles, Functions, and Mechanisms of Long Non-coding RNAs in Cancer

被引：0
|
作者：
Yiwen Fang [1 ]
Melissa J.Fullwood [1 ,2 ,3 ,4 ]
机构：
[1] Cancer Science Institute of Singapore, National University of Singapore
[2] School of Biological Sciences, Nanyang Technological University
[3] Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR)
[4] Yale-NUS Liberal Arts College
来源：
Genomics,Proteomics & Bioinformatics | 2016年 / 14卷 / 01期
基金：
新加坡国家研究基金会;
关键词：
lnc RNAs; Chromatin; Transcription regulation; Antisense oligonucleotides; Cancer;
D O I：
暂无
中图分类号：
R730.2 [肿瘤病理学、病因学];
学科分类号：
100214 ;
摘要：
Long non-coding RNAs(lnc RNAs) play important roles in cancer. They are involved in chromatin remodeling, as well as transcriptional and post-transcriptional regulation, through a variety of chromatin-based mechanisms and via cross-talk with other RNA species. lnc RNAs can function as decoys, scaffolds, and enhancer RNAs. This review summarizes the characteristics of lnc RNAs, including their roles, functions, and working mechanisms, describes methods for identifying and annotating lnc RNAs, and discusses future opportunities for lnc RNA-based therapies using antisense oligonucleotides.
引用
收藏
页码：42 / 54
页数：13
相关论文
共 50 条
  • [1] Roles, Functions, and Mechanisms of Long Non-coding RNAs in Cancer
    Yiwen Fang
    Melissa JFullwood
    Genomics,Proteomics & Bioinformatics, 2016, (01) : 42 - 54
  • [2] Roles, Functions, and Mechanisms of Long Non-coding RNAs in Cancer
    Fang, Yiwen
    Fullwood, Melissa J.
    GENOMICS PROTEOMICS & BIOINFORMATICS, 2016, 14 (01) : 42 - 54
  • [3] Roles and Mechanisms of Long Non-Coding RNAs in Breast Cancer
    Su, Jia
    Deng, Lihao
    Wang, Yan-Dong
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 24 (01)
  • [4] The Regulatory Functions and the Mechanisms of Long Non-Coding RNAs in Cervical Cancer
    Yang, Qiwei
    Al-Hendy, Ayman
    CELLS, 2022, 11 (07)
  • [5] Mechanisms and functions of long non-coding RNAs in glioma
    Chen, Xingjie
    Guo, Gaochao
    Lu, Yalin
    Wang, Shuaishuai
    Zhang, Yu
    Huang, Qiang
    ONCOLOGY REPORTS, 2021, 45 (04)
  • [6] The roles of long non-coding RNAs in lung cancer
    Cao, Zhe
    Oyang, Linda
    Luo, Xia
    Xia, Longzheng
    Hu, Jiaqi
    Lin, Jinguan
    Tan, Shiming
    Tang, Yanyan
    Zhou, Yujuan
    Cao, Deliang
    Liao, Qianjin
    JOURNAL OF CANCER, 2022, 13 (01): : 174 - 183
  • [7] Emerging roles of long non-coding RNAs in cancer
    Chatterjee, Manjima
    Sengupta, Sonali
    JOURNAL OF BIOSCIENCES, 2019, 44 (01)
  • [8] Roles of long non-coding RNAs in cervical cancer
    Luo, Fangzhen
    Wen, Yating
    Zhou, Hui
    Li, Zhongyu
    LIFE SCIENCES, 2020, 256
  • [9] Emerging roles of long non-coding RNAs in cancer
    Manjima Chatterjee
    Sonali Sengupta
    Journal of Biosciences, 2019, 44
  • [10] Non-Coding RNAs in Colorectal Cancer: Their Functions and Mechanisms
    Jia, Zimo
    An, Jiaqi
    Liu, Ziyuan
    Zhang, Fan
    FRONTIERS IN ONCOLOGY, 2022, 12
12345