Roles, Functions, and Mechanisms of Long Non-coding RNAs in Cancer

被引：0
|
作者：
Yiwen Fang [1 ]
Melissa J.Fullwood [1 ,2 ,3 ,4 ]
机构：
[1] Cancer Science Institute of Singapore, National University of Singapore
[2] School of Biological Sciences, Nanyang Technological University
[3] Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR)
[4] Yale-NUS Liberal Arts College
来源：
Genomics,Proteomics & Bioinformatics | 2016年 / 14卷 / 01期
基金：
新加坡国家研究基金会;
关键词：
lnc RNAs; Chromatin; Transcription regulation; Antisense oligonucleotides; Cancer;
D O I：
暂无
中图分类号：
R730.2 [肿瘤病理学、病因学];
学科分类号：
100214 ;
摘要：
Long non-coding RNAs(lnc RNAs) play important roles in cancer. They are involved in chromatin remodeling, as well as transcriptional and post-transcriptional regulation, through a variety of chromatin-based mechanisms and via cross-talk with other RNA species. lnc RNAs can function as decoys, scaffolds, and enhancer RNAs. This review summarizes the characteristics of lnc RNAs, including their roles, functions, and working mechanisms, describes methods for identifying and annotating lnc RNAs, and discusses future opportunities for lnc RNA-based therapies using antisense oligonucleotides.
引用
收藏
页码：42 / 54
页数：13
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