Intratumoural heterogeneity generated by Notch signalling promotes small-cell lung cancer

被引：0
|
作者：
Jing Shan Lim
Alvaro Ibaseta
Marcus M. Fischer
Belinda Cancilla
Gilbert O’Young
Sandra Cristea
Vincent C. Luca
Dian Yang
Nadine S. Jahchan
Cécile Hamard
Martine Antoine
Marie Wislez
Christina Kong
Jennifer Cain
Yu-Wang Liu
Ann M. Kapoun
K. Christopher Garcia
Timothy Hoey
Christopher L. Murriel
Julien Sage
机构：
[1] Stanford University School of Medicine,Department of Pediatrics
[2] Stanford University School of Medicine,Department of Genetics
[3] OncoMed Pharmaceuticals,Department of Molecular and Cellular Physiology
[4] Inc.,Department of Structural Biology
[5] Stanford University School of Medicine,Department of Pathology
[6] Stanford University School of Medicine,undefined
[7] Howard Hughes Medical Institute,undefined
[8] Stanford University School of Medicine,undefined
[9] Sorbonne Universités,undefined
[10] UPMC Univ Paris 06,undefined
[11] GRC n°04,undefined
[12] AP-HP,undefined
[13] Hôpital Tenon,undefined
[14] Service de Pneumologie,undefined
[15] Stanford University School of Medicine,undefined
来源：
Nature | 2017年 / 545卷
关键词：
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学科分类号：
摘要：
In a mouse model of small-cell lung cancer and in human tumours, activation of the Notch pathway can lead to a cell fate switch of neuroendocrine cells to less proliferative non-neuroendocrine cells, generating intratumoural heterogeneity.
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页码：360 / 364
页数：4
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