The Stability of Recombinant Human Growth Hormone in Poly(lactic-co-glycolic acid) (PLGA) Microspheres

被引：0
|
作者：
Jeffrey L. Cleland
Anne Mac
Brooks Boyd
Janet Yang
Eileen T. Duenas
Douglas Yeung
Dennis Brooks
Chung Hsu
Herman Chu
Venkat Mukku
Andrew J. S. Jones
机构：
[1] Genentech,Department of Pharmaceutical Research & Development
[2] Inc.,School of Pharmacy
[3] University of California,Department of Chemical Engineering
[4] University of California,Department of Quality Control
[5] Genentech,Department of Analytical Chemistry
[6] Inc.,undefined
[7] Genentech,undefined
[8] Inc.,undefined
来源：
Pharmaceutical Research | 1997年 / 14卷
关键词：
growth hormone; stability; poly(lactic-co-glycolic acid); microencapsulation; degradation; sustained release;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Purpose. The development of a sustained release formulation for recombinant human growth hormone (rhGH) as well as other proteins requires that the protein be stable at physiological conditions during its in vivo lifetime. Poly(lactic-co-glycolic acid) (PLGA) microspheres may provide an excellent sustained release formulation for proteins, if protein stability can be maintained.
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页码：420 / 425
页数：5
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