The Stability of Recombinant Human Growth Hormone in Poly(lactic-co-glycolic acid) (PLGA) Microspheres

被引：0
|
作者：
Jeffrey L. Cleland
Anne Mac
Brooks Boyd
Janet Yang
Eileen T. Duenas
Douglas Yeung
Dennis Brooks
Chung Hsu
Herman Chu
Venkat Mukku
Andrew J. S. Jones
机构：
[1] Genentech,Department of Pharmaceutical Research & Development
[2] Inc.,School of Pharmacy
[3] University of California,Department of Chemical Engineering
[4] University of California,Department of Quality Control
[5] Genentech,Department of Analytical Chemistry
[6] Inc.,undefined
[7] Genentech,undefined
[8] Inc.,undefined
来源：
Pharmaceutical Research | 1997年 / 14卷
关键词：
growth hormone; stability; poly(lactic-co-glycolic acid); microencapsulation; degradation; sustained release;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Purpose. The development of a sustained release formulation for recombinant human growth hormone (rhGH) as well as other proteins requires that the protein be stable at physiological conditions during its in vivo lifetime. Poly(lactic-co-glycolic acid) (PLGA) microspheres may provide an excellent sustained release formulation for proteins, if protein stability can be maintained.
引用
收藏
页码：420 / 425
页数：5
相关论文
共 50 条
  • [21] Preparation and Characterization of Negatively Charged Poly(Lactic-co-Glycolic Acid) Microspheres
    Xu, Qingguo
    Crossley, Alison
    Czernuszka, Jan
    JOURNAL OF PHARMACEUTICAL SCIENCES, 2009, 98 (07) : 2377 - 2389
  • [22] Poly(lactic-co-glycolic acid) Microspheres Containing a Recombinant Parathyroid Hormone (1-34) for Sustained Release in a Rat Model
    Baskaran, R.
    Lee, C. J.
    Kang, S. M.
    Oh, Y.
    Jin, S. E.
    Lee, D. H.
    Yang, S. G.
    INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2018, 80 (05) : 837 - 843
  • [23] Poly(lactic-co-glycolic) Acid (PLGA) Nanoparticles and Transdermal Drug Delivery: An Overview
    Kumar, Lalit
    Kukreti, Gauree
    Rana, Ritesh
    Chaurasia, Himanshu
    Sharma, Anchal
    Sharma, Neelam
    Komal
    CURRENT PHARMACEUTICAL DESIGN, 2023, 29 (37) : 2940 - 2953
  • [24] Particulate Systems Based on Poly(Lactic-co-Glycolic)Acid (pLGA) for Immunotherapy of Cancer
    Rahimian, Sima
    Fransen, Marieke F.
    Kleinovink, Jan Willem
    Amidi, Maryam
    Ossendorp, Ferry
    Hennink, Wim E.
    CURRENT PHARMACEUTICAL DESIGN, 2015, 21 (29) : 4201 - 4216
  • [25] Tuning the Size of Poly(lactic-co-glycolic Acid) (PLGA) Nanoparticles Fabricated by Nanoprecipitation
    Huang, Wei
    Zhang, Chenming
    BIOTECHNOLOGY JOURNAL, 2018, 13 (01)
  • [26] Benign preparation of aqueous core poly lactic-co-glycolic acid (PLGA) microcapsules
    Nomura, Toshiyuki
    Routh, Alexander F.
    JOURNAL OF COLLOID AND INTERFACE SCIENCE, 2018, 513 : 1 - 9
  • [27] Poly Lactic-co-Glycolic Acid (PLGA) as Biodegradable Controlled Drug Delivery Carrier
    Makadia, Hirenkumar K.
    Siegel, Steven J.
    POLYMERS, 2011, 3 (03) : 1377 - 1397
  • [28] Experimental Comparative Study of the Histotoxicity of Poly(Lactic-co-Glycolic Acid) copolymer and Poly(Lactic-co-Glycolic Acid)-Poly(Isoprene) Blend
    Kim, Jung Ho
    Marques, Douglas Ramos
    Faller, Gustavo Juliani
    Collares, Marcus Vinicius
    Rodriguez, Rubens
    dos Santos, Luis Alberto
    Dias, Diego da Silva
    POLIMEROS-CIENCIA E TECNOLOGIA, 2014, 24 (05): : 529 - 535
  • [29] Immune responses in mice of β-galactosiclase adsorbed or encapsulated in poly(lactic acid) and poly(lactic-co-glycolic acid) microspheres
    Stivaktakis, N
    Nikou, K
    Panagi, Z
    Beletsi, A
    Leondiadis, L
    Avgoustakis, K
    JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 2005, 73A (03) : 332 - 338
  • [30] Culturing Primary Human Osteoblasts on Electrospun Poly(lactic-co-glycolic acid) and Poly(lactic-co-glycolic acid)/Nanohydroxyapatite Scaffolds for Bone Tissue Engineering
    Li, Mengmeng
    Liu, Wenwen
    Sun, Jiashu
    Xianyu, Yunlei
    Wang, Jidong
    Zhang, Wei
    Zheng, Wenfu
    Huang, Deyong
    Di, Shiyu
    Long, Yun-Ze
    Jiang, Xingyu
    ACS APPLIED MATERIALS & INTERFACES, 2013, 5 (13) : 5921 - 5926
12345