The Stability of Recombinant Human Growth Hormone in Poly(lactic-co-glycolic acid) (PLGA) Microspheres

被引：0
|
作者：
Jeffrey L. Cleland
Anne Mac
Brooks Boyd
Janet Yang
Eileen T. Duenas
Douglas Yeung
Dennis Brooks
Chung Hsu
Herman Chu
Venkat Mukku
Andrew J. S. Jones
机构：
[1] Genentech,Department of Pharmaceutical Research & Development
[2] Inc.,School of Pharmacy
[3] University of California,Department of Chemical Engineering
[4] University of California,Department of Quality Control
[5] Genentech,Department of Analytical Chemistry
[6] Inc.,undefined
[7] Genentech,undefined
[8] Inc.,undefined
来源：
Pharmaceutical Research | 1997年 / 14卷
关键词：
growth hormone; stability; poly(lactic-co-glycolic acid); microencapsulation; degradation; sustained release;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Purpose. The development of a sustained release formulation for recombinant human growth hormone (rhGH) as well as other proteins requires that the protein be stable at physiological conditions during its in vivo lifetime. Poly(lactic-co-glycolic acid) (PLGA) microspheres may provide an excellent sustained release formulation for proteins, if protein stability can be maintained.
引用
收藏
页码：420 / 425
页数：5
相关论文
共 50 条
  • [1] The stability of recombinant human growth hormone in poly(lactic-co-glycolic acid) (PLGA) microspheres
    Cleland, JL
    Mac, A
    Boyd, B
    Yang, J
    Duenas, ET
    Yeung, D
    Brooks, D
    Hsu, C
    Chu, H
    Mukku, V
    Jones, AJS
    PHARMACEUTICAL RESEARCH, 1997, 14 (04) : 420 - 425
  • [2] Recombinant human growth hormone poly(lactic-co-glycolic acid) (PLGA) microspheres provide a long lasting effect
    Cleland, JL
    Duenas, E
    Daugherty, A
    Marian, M
    Yang, J
    Wilson, M
    Celniker, AC
    Shahzamani, A
    Quarmby, V
    Chu, H
    Mukku, V
    Mac, A
    Roussakis, M
    Gillette, N
    Boyd, B
    Yeung, D
    Brooks, D
    Maa, YF
    Hsu, C
    Jones, AJS
    JOURNAL OF CONTROLLED RELEASE, 1997, 49 (2-3) : 193 - 205
  • [3] Recombinant human growth hormone poly(lactic-co-glycolic acid) (PLGA) microspheres provide a long lasting effect
    Journal of Controlled Release, 49 (2-3):
  • [4] Recombinant human growth hormone poly(lactic-co-glycolic acid) microsphere formulation development
    Cleland, JL
    Johnson, OL
    Putney, S
    Jones, AJS
    ADVANCED DRUG DELIVERY REVIEWS, 1997, 28 (01) : 71 - 84
  • [5] Stability of insulin during the erosion of poly(lactic acid) and poly(lactic-co-glycolic acid) microspheres
    Ibrahim, MA
    Ismail, A
    Fetouh, MI
    Göpferich, A
    JOURNAL OF CONTROLLED RELEASE, 2005, 106 (03) : 241 - 252
  • [6] The Evaluation of Fabrication Parameters Process Effect on the Formation of Poly(lactic-co-glycolic acid) (PLGA) Microspheres
    Trinh-Quang Bao
    Lee, Byong-Taek
    BULLETIN OF THE KOREAN CHEMICAL SOCIETY, 2011, 32 (05) : 1465 - 1470
  • [7] Self-encapsulating Poly(lactic-co-glycolic acid) (PLGA) Microspheres for Intranasal Vaccine Delivery
    Bailey, Brittany A.
    Desai, Kashappa-Goud H.
    Ochyl, Lukasz J.
    Ciotti, Susan M.
    Moon, James J.
    Schwendeman, Steven P.
    MOLECULAR PHARMACEUTICS, 2017, 14 (09) : 3228 - 3237
  • [8] Visual Evidence of Acidic Environment Within Degrading Poly(lactic-co-glycolic acid) (PLGA) Microspheres
    Karen Fu
    Daniel W. Pack
    Alexander M. Klibanov
    Robert Langer
    Pharmaceutical Research, 2000, 17 : 100 - 106
  • [9] Preparation, characterization and in vitro evaluation of IVM loaded poly(lactic-co-glycolic acid) (PLGA) microspheres
    Li, Guiyu
    Lu, Xihong
    Li, Xuehu
    Tao, Lei
    Liang, Jianping
    ADVANCED MATERIALS AND PROCESSES, PTS 1-3, 2011, 311-313 : 1751 - +
  • [10] Visual evidence of acidic environment within degrading poly(lactic-co-glycolic acid) (PLGA) microspheres
    Fu, K
    Pack, DW
    Klibanov, AM
    Langer, R
    PHARMACEUTICAL RESEARCH, 2000, 17 (01) : 100 - 106
12345