Characterization of two phase I metabolites of bendamustine in human liver microsomes and in cancer patients treated with bendamustine hydrochloride

被引：0
|
作者：
Jens Teichert
Frank Baumann
Qi Chao
Craig Franklin
Brandy Bailey
Lothar Hennig
Karel Caca
Konrad Schoppmeyer
Ulrich Patzak
Rainer Preiss
机构：
[1] Universität Leipzig,Institut für Klinische Pharmakologie
[2] Salmedix Inc.,Institut für Organische Chemie
[3] Universität Leipzig,Medizinische Klinik und Poliklinik II
[4] Universitätsklinikum Leipzig AöR,undefined
[5] Astellas Pharma GmbH,undefined
来源：
Cancer Chemotherapy and Pharmacology | 2007年 / 59卷
关键词：
Bendamustine; Metabolism; Cytochrome P450; Cytotoxic activity;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
页码：759 / 770
页数：11
相关论文
共 50 条
  • [31] Characterization of in vitro phase I metabolites of methamnetamine in human liver microsomes by liquid chromatography-quadrupole time-of-flight mass spectrometry
    Hong, Young-ki
    Kim, Young-Hoon
    Lee, Jin-Moo
    Yoo, Hye Hyun
    Choi, Sun-Ok
    Kang, Mi Sun
    INTERNATIONAL JOURNAL OF LEGAL MEDICINE, 2021, 135 (04) : 1471 - 1476
  • [32] Phase I-II Study of Bendamustine in Patients With Acute Leukemia and High Risk Myelodysplastic Syndrome
    Chacar, Christelle
    Jabbour, Elias
    Ravandi, Farhad
    Borthakur, Gautam
    Kadia, Tapan
    Estrov, Zeev
    Rios, Mary Beth
    Cortes, Jorge
    Kantarjian, Hagop
    CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, 2012, 12 (03): : 197 - 200
  • [33] a Phase I Trial of Bendamustine in Combination with Clofarabine and Etoposide in Pediatric Patients with Relapsed or Refractory Hematologic Malignancies
    Jeha, Sima
    Metzger, Monika L.
    Crews, Kristine R.
    Campbell, Patrick
    Ribeiro, Raul C.
    Cheng, Cheng
    Peyton, Melissa
    Panetta, Carl
    Yang, Jun
    Pui, Ching-Hon
    Bhojwani, Deepa
    BLOOD, 2016, 128 (22)
  • [34] Severe and prolonged lymphopenia observed in patients treated with bendamustine and erlotinib for metastatic triple negative breast cancer
    Layman, Rachel M.
    Ruppert, Amy S.
    Lynn, Melinda
    Mrozek, Ewa
    Ramaswamy, Bhuvaneswari
    Lustberg, Maryam B.
    Wesolowski, Robert
    Ottman, Susan
    Carothers, Sarah
    Bingman, Anissa
    Reinbolt, Raquel
    Kraut, Eric H.
    Shapiro, Charles L.
    CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2013, 71 (05) : 1183 - 1190
  • [35] Characterization of in vitro phase I metabolites of methamnetamine in human liver microsomes by liquid chromatography-quadrupole time-of-flight mass spectrometry
    Young-ki Hong
    Young-Hoon Kim
    Jin-Moo Lee
    Hye Hyun Yoo
    Sun-Ok Choi
    Mi Sun Kang
    International Journal of Legal Medicine, 2021, 135 : 1471 - 1476
  • [36] A phase I dose-ranging study of bendamustine and rituximab in chronic lymphocytic leukemia patients with comorbidities
    Danilov, Alexey V.
    Lewis, Lionel D.
    Lansigan, Frederick
    Roudaia, Liya
    Findley, Darcie L.
    Jones, Susan Y.
    Highhouse, Brian
    Beaulieu, Bernard B.
    Brown, Jennifer R.
    BRITISH JOURNAL OF HAEMATOLOGY, 2017, 178 (05) : 820 - 823
  • [37] Repeated administration of short infusions of bendamustine: a phase I study in patients with advanced progressive solid tumours
    P. Schöffski
    T. Hagedorn
    V. Grünwald
    H. Paul
    K. Merkle
    R. Kowalski
    A. Ganser
    Journal of Cancer Research and Clinical Oncology, 2000, 126 : 41 - 47
  • [38] Phase I/II study of carfilzomib, bendamustine, and dexamethasone (CBD) in patients with newly diagnosed multiple myeloma
    Siyang Leng
    Divaya Bhutani
    Shahzad Raza
    Amer Assal
    Samuel Pan
    Jianhua Hu
    Alexander Wei
    Markus Mapara
    Suzanne Lentzsch
    Blood Cancer Journal, 10
  • [39] Phase I/II study of carfilzomib, bendamustine, and dexamethasone (CBD) in patients with newly diagnosed multiple myeloma
    Leng, Siyang
    Bhutani, Divaya
    Raza, Shahzad
    Assal, Amer
    Pan, Samuel
    Hu, Jianhua
    Wei, Alexander
    Mapara, Markus
    Lentzsch, Suzanne
    BLOOD CANCER JOURNAL, 2020, 10 (02)
  • [40] Repeated administration of short infusions of bendamustine:: a phase I study in patients with advanced progressive solid tumours
    Schöffski, P
    Hagedorn, T
    Grünwald, V
    Paul, H
    Merkle, K
    Kowalski, R
    Ganser, A
    JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 2000, 126 (01) : 41 - 47
12345