Characterization of two phase I metabolites of bendamustine in human liver microsomes and in cancer patients treated with bendamustine hydrochloride

被引:0
|
作者
Jens Teichert
Frank Baumann
Qi Chao
Craig Franklin
Brandy Bailey
Lothar Hennig
Karel Caca
Konrad Schoppmeyer
Ulrich Patzak
Rainer Preiss
机构
[1] Universität Leipzig,Institut für Klinische Pharmakologie
[2] Salmedix Inc.,Institut für Organische Chemie
[3] Universität Leipzig,Medizinische Klinik und Poliklinik II
[4] Universitätsklinikum Leipzig AöR,undefined
[5] Astellas Pharma GmbH,undefined
来源
关键词
Bendamustine; Metabolism; Cytochrome P450; Cytotoxic activity;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
页码:759 / 770
页数:11
相关论文
共 50 条
  • [21] Phase I/II study with bendamustine hydrochloride in patients with multiple myeloma relapsing after high dose therapy and autologous stem cell transplantation
    Knop, S
    Straka, C
    Hebart, H
    Haen, M
    Kanz, L
    Einsele, H
    BLOOD, 2003, 102 (11) : 383B - 383B
  • [22] Bendamustine as salvage treatment in patients with advanced progressive breast cancer:: a phase II study
    Höffken, K
    Merkle, K
    Schönfelder, M
    Anger, G
    Brandtner, M
    Ridwelski, K
    Seeber, S
    JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 1998, 124 (11) : 627 - 632
  • [23] Bendamustine as salvage treatment in patients with advanced progressive breast cancer: a phase II study
    K. Höffken
    Kh. Merkle
    M. Schönfelder
    G. Anger
    M. Brandtner
    K. Ridwelski
    S. Seeber
    Journal of Cancer Research and Clinical Oncology, 1998, 124 : 627 - 632
  • [24] Phase I trial of radiochemotherapy with bendamustine in patients with recurrent squamous cell carcinoma of the head and neck
    Bottke, Dirk
    Bathe, Kathrin
    Wiegel, Thomas
    Hinkelbein, Wolfgang
    STRAHLENTHERAPIE UND ONKOLOGIE, 2007, 183 (03) : 128 - 132
  • [25] Phase I/II study with bendamustine hydrochloride in patients with multiple myeloma relapsing after high-dose therapy and autologous stem cell transplantation
    Knop, S
    Straka, C
    Hebart, H
    Haen, M
    Kanz, L
    Einsele, H
    BONE MARROW TRANSPLANTATION, 2004, 33 : S160 - S160
  • [26] Phase II study of bendamustine in patients with relapsed or cisplatin-refractory germ cell cancer
    Kollmannsberger, C
    Gerl, A
    Schleucher, N
    Beyer, J
    Kuczyk, M
    Rick, O
    Gasper, J
    Sosada, M
    Rie, C
    Kanz, L
    Bokemeyer, C
    ANTI-CANCER DRUGS, 2000, 11 (07) : 535 - 539
  • [27] Severe and Prolonged Lymphopenia Observed In Patients Treated with Bendamustine and Erlotinib for Metastatic Triple Negative Breast Cancer
    Layman, Rachel M.
    Ruppert, Amy S.
    Lynn, Melinda
    Mrozek, Ewa
    Ramaswamy, Bhuvaneswari
    Lustberg, Maryam B.
    Susan, Ottman
    Carothers, Sarah
    Kraut, Eric H.
    Shapiro, Charles L.
    BLOOD, 2010, 116 (21) : 726 - 727
  • [28] A Phase I Study of Bendamustine Combined with Lenalidomide and Dexamethasone in Patients with Refractory or Relapsed Multiple Myeloma.
    Lentzsch, Suzanne
    O'Sullivan, Amy
    Lalo, Silvana
    Kruppa, Carrie
    Gardner, Diane
    Kennedy, Ryan C.
    Burt, Steve
    Mapara, Markus Y.
    Redner, Robert
    Roodman, David
    Volkin, Robert L.
    Zonder, Jeffrey
    BLOOD, 2009, 114 (22) : 736 - 736
  • [29] Severe and prolonged lymphopenia observed in patients treated with bendamustine and erlotinib for metastatic triple negative breast cancer
    Rachel M. Layman
    Amy S. Ruppert
    Melinda Lynn
    Ewa Mrozek
    Bhuvaneswari Ramaswamy
    Maryam B. Lustberg
    Robert Wesolowski
    Susan Ottman
    Sarah Carothers
    Anissa Bingman
    Raquel Reinbolt
    Eric H. Kraut
    Charles L. Shapiro
    Cancer Chemotherapy and Pharmacology, 2013, 71 : 1183 - 1190
  • [30] In vitro phase I metabolism of vinclozolin by human liver microsomes
    Cruz-Hurtado, Marycarmen
    de Lourdes Lopez-Gonzalez, Ma
    Mondragon, Victor
    Sierra-Santoyo, Adolfo
    XENOBIOTICA, 2019, 49 (08) : 895 - 904