Mitochondria can power cells to life and death: Role of mitochondria in apoptosis

被引:0
|
作者
Sah N.K. [1 ]
Taneja T.K. [1 ,3 ]
Hasnain S.E. [1 ,2 ]
机构
[1] Eukaryotic Gene Expression Laboratory, National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi
[2] Laboratory of Molecular & Cellular Biology, CDFD, CDFD Interim Building Complex 7-18, E & F, Nacharam, Hyderabad
[3] Department of Medical Elementology & Toxicology, Jamia Hamdard, Hamdard Nagar, New Delhi
关键词
African Swine Fever; African Swine Fever Virus; Apoptotic Machinery; Growth Factor Withdrawal; Power House;
D O I
10.1007/BF02837908
中图分类号
学科分类号
摘要
Mitochondria serve as power houses of cells but they also possess ‘covered’ knives to kill the cells. A number of intrinsic and extrinsic factors exist which regulate cell killing by mitochondria. Caspases are comparable to a surgeon’s knife, which can be used to sculpt organisms, get rid of wayward, redundant and incorrigibly damaged cells, but can spell doom if not controlled properly. © 2000, Indian Academy of Sciences.
引用
收藏
页码:74 / 84
页数:10
相关论文
共 50 条
  • [11] Mitochondria in the life and death of neurons
    Budd, SL
    Nicholls, DG
    ESSAYS IN BIOCHEMISTRY, VOL 33: MOLECULAR BIOLOGY OF THE BRAIN, 1999, 33 : 43 - 52
  • [12] Apoptosis - Mitochondria - the death signal integrators
    Brenner, C
    Kroemer, G
    SCIENCE, 2000, 289 (5482) : 1150 - 1151
  • [13] Apoptosis and aging: Role of the mitochondria
    Pollack, M
    Leeuwenburgh, C
    JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 2001, 56 (11): : B475 - B482
  • [14] Role of mitochondria in apoptosis and necrosis
    Nieminen, AL
    FASEB JOURNAL, 2001, 15 (05): : A1069 - A1069
  • [15] Role of mitochondria in neuronal apoptosis
    Gorman, AM
    Ceccatelli, S
    Orrenius, S
    DEVELOPMENTAL NEUROSCIENCE, 2000, 22 (5-6) : 348 - 358
  • [16] The expanding role of mitochondria in apoptosis
    Wang, XD
    GENES & DEVELOPMENT, 2001, 15 (22) : 2922 - 2933
  • [17] Role of mitochondria in ciprofloxacin induced apoptosis in bladder cancer cells
    Aranha, O
    Zhu, LP
    Alhasan, S
    Wood, DP
    Kuo, TH
    Sarkar, FH
    JOURNAL OF UROLOGY, 2002, 167 (03): : 1288 - 1294
  • [18] Estrogens regulate life and death in mitochondria
    Carolyn M. Klinge
    Journal of Bioenergetics and Biomembranes, 2017, 49 : 307 - 324
  • [19] Heart mitochondria:: gates of life and death
    Gustafsson, Asa B.
    Gottlieb, Roberta A.
    CARDIOVASCULAR RESEARCH, 2008, 77 (02) : 334 - 343
  • [20] Mitochondria: Life, Death, and the In-Between
    Scheffler, Tracy L.
    JOURNAL OF ANIMAL SCIENCE, 2023, 101