Mitochondria can power cells to life and death: Role of mitochondria in apoptosis

被引:0
|
作者
Sah N.K. [1 ]
Taneja T.K. [1 ,3 ]
Hasnain S.E. [1 ,2 ]
机构
[1] Eukaryotic Gene Expression Laboratory, National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi
[2] Laboratory of Molecular & Cellular Biology, CDFD, CDFD Interim Building Complex 7-18, E & F, Nacharam, Hyderabad
[3] Department of Medical Elementology & Toxicology, Jamia Hamdard, Hamdard Nagar, New Delhi
关键词
African Swine Fever; African Swine Fever Virus; Apoptotic Machinery; Growth Factor Withdrawal; Power House;
D O I
10.1007/BF02837908
中图分类号
学科分类号
摘要
Mitochondria serve as power houses of cells but they also possess ‘covered’ knives to kill the cells. A number of intrinsic and extrinsic factors exist which regulate cell killing by mitochondria. Caspases are comparable to a surgeon’s knife, which can be used to sculpt organisms, get rid of wayward, redundant and incorrigibly damaged cells, but can spell doom if not controlled properly. © 2000, Indian Academy of Sciences.
引用
收藏
页码:74 / 84
页数:10
相关论文
共 50 条
  • [1] Mitochondria - potential role in cell life and death
    Griffiths, EJ
    CARDIOVASCULAR RESEARCH, 2000, 46 (01) : 24 - 27
  • [2] Programmed cell death and apoptosis. The role of mitochondria
    Dubin, M
    Stoppani, AOM
    MEDICINA-BUENOS AIRES, 2000, 60 (03) : 375 - 386
  • [3] Role of mitochondria in apoptosis
    Gottlieb, RA
    CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION, 2000, 10 (3-4): : 231 - 239
  • [4] The role of mitochondria in apoptosis
    Jeong, Seon-Yong
    Seol, Dai-Wu
    BMB REPORTS, 2008, 41 (01) : 11 - 22
  • [5] The role of mitochondria in apoptosis
    Kroemer, G
    EUROPEAN JOURNAL OF CANCER, 1999, 35 : S307 - S307
  • [6] The Role of Mitochondria in Apoptosis
    Wang, Chunxin
    Youle, Richard J.
    ANNUAL REVIEW OF GENETICS, 2009, 43 : 95 - 118
  • [7] Role of mitochondria in apoptosis
    Gulbins, E
    Dreschers, S
    Bock, J
    EXPERIMENTAL PHYSIOLOGY, 2003, 88 (01) : 85 - 90
  • [8] Mitochondria: Releasing power for life and unleashing the machineries of death
    Newmeyer, DD
    Ferguson-Miller, S
    CELL, 2003, 112 (04) : 481 - 490
  • [9] Mitochondria at the crossroads of life and death
    Adams, A
    SCIENTIST, 2004, 18 (19): : 25 - 29
  • [10] Mitochondria in the life and death of neurons
    Budd, SL
    Nicholls, DG
    ESSAYS IN BIOCHEMISTRY, VOL 33, 1998, 1998, 33 : 43 - 52