Decreased amyloid-β and increased neuronal hyperactivity by immunotherapy in Alzheimer's models

被引：0
|
作者：
Marc Aurel Busche
Christine Grienberger
Aylin D Keskin
Beomjong Song
Ulf Neumann
Matthias Staufenbiel
Hans Förstl
Arthur Konnerth
机构：
[1] Institute of Neuroscience,Department of Psychiatry and Psychotherapy
[2] Technische Universität München,Department of Cellular Neurology
[3] Technische Universität München,undefined
[4] Munich Cluster for Systems Neurology (SyNergy),undefined
[5] Janelia Farm Research Campus,undefined
[6] Howard Hughes Medical Institute,undefined
[7] Novartis Institute for BioMedical Research,undefined
[8] Hertie Institute for Clinical Brain Research,undefined
[9] University of Tübingen,undefined
来源：
Nature Neuroscience | 2015年 / 18卷
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学科分类号：
摘要：
Immunotherapy with antibodies targeting the amyloid-β peptide has yet to show any cognitive benefit in Alzheimer's disease patients in clinical trials. In vivo two-photon imaging in mouse models of Alzheimer's disease now reveals that these antibodies do not alleviate neuronal dysfunction and can even worsen it.
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页码：1725 / 1727
页数：2
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