Decreased amyloid-β and increased neuronal hyperactivity by immunotherapy in Alzheimer's models

被引：0
|
作者：
Marc Aurel Busche
Christine Grienberger
Aylin D Keskin
Beomjong Song
Ulf Neumann
Matthias Staufenbiel
Hans Förstl
Arthur Konnerth
机构：
[1] Institute of Neuroscience,Department of Psychiatry and Psychotherapy
[2] Technische Universität München,Department of Cellular Neurology
[3] Technische Universität München,undefined
[4] Munich Cluster for Systems Neurology (SyNergy),undefined
[5] Janelia Farm Research Campus,undefined
[6] Howard Hughes Medical Institute,undefined
[7] Novartis Institute for BioMedical Research,undefined
[8] Hertie Institute for Clinical Brain Research,undefined
[9] University of Tübingen,undefined
来源：
Nature Neuroscience | 2015年 / 18卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Immunotherapy with antibodies targeting the amyloid-β peptide has yet to show any cognitive benefit in Alzheimer's disease patients in clinical trials. In vivo two-photon imaging in mouse models of Alzheimer's disease now reveals that these antibodies do not alleviate neuronal dysfunction and can even worsen it.
引用
收藏
页码：1725 / 1727
页数：2
相关论文
共 50 条
  • [31] Asymmetries of amyloid-β burden and neuronal dysfunction are positively correlated in Alzheimer's disease
    Frings, Lars
    Hellwig, Sabine
    Spehl, Timo S.
    Bormann, Tobias
    Buchert, Ralph
    Vach, Werner
    Minkova, Lora
    Heimbach, Bernhard
    Kloeppel, Stefan
    Meyer, Philipp T.
    BRAIN, 2015, 138 : 3089 - 3099
  • [32] Decreased CSF clearance and increased brain amyloid in Alzheimer's disease
    Li, Yi
    Rusinek, Henry
    Butler, Tracy
    Glodzik, Lidia
    Pirraglia, Elizabeth
    Babich, John
    Mozley, P. David
    Nehmeh, Sadek
    Pahlajani, Silky
    Wang, Xiuyuan
    Tanzi, Emily B.
    Zhou, Liangdong
    Strauss, Sara
    Carare, Roxana O.
    Theise, Neil
    Okamura, Nobuyuki
    de Leon, Mony J.
    FLUIDS AND BARRIERS OF THE CNS, 2022, 19 (01)
  • [33] Decreased CSF clearance and increased brain amyloid in Alzheimer’s disease
    Yi Li
    Henry Rusinek
    Tracy Butler
    Lidia Glodzik
    Elizabeth Pirraglia
    John Babich
    P. David Mozley
    Sadek Nehmeh
    Silky Pahlajani
    Xiuyuan Wang
    Emily B. Tanzi
    Liangdong Zhou
    Sara Strauss
    Roxana O. Carare
    Neil Theise
    Nobuyuki Okamura
    Mony J. de Leon
    Fluids and Barriers of the CNS, 19
  • [34] Enhanced Neurite Outgrowth and Branching Precede Increased Amyloid-β-Induced Neuronal Apoptosis in a Novel Alzheimer's Disease Model
    Saad, Yaara
    Segal, Daniel
    Ayali, Amir
    JOURNAL OF ALZHEIMERS DISEASE, 2015, 43 (03) : 993 - 1006
  • [35] Alzheimer's amyloid immunotherapy
    Orgogozo, J. -M.
    JOURNAL OF NEUROLOGY, 2006, 253 : 5 - 6
  • [36] Hippocampal Deficits in Amyloid-β-Related Rodent Models of Alzheimer's Disease
    Vyas, Yukti
    Montgomery, Johanna M.
    Cheyne, Juliette E.
    FRONTIERS IN NEUROSCIENCE, 2020, 14
  • [37] Myelin dysfunction drives amyloid-β deposition in models of Alzheimer's disease
    Depp, Constanze
    Sun, Ting
    Sasmita, Andrew Octavian
    Spieth, Lena
    Berghoff, Stefan A.
    Nazarenko, Taisiia
    Overhoff, Katharina
    Steixner-Kumar, Agnes A.
    Subramanian, Swati
    Arinrad, Sahab
    Ruhwedel, Torben
    Moebius, Wiebke
    Goebbels, Sandra
    Saher, Gesine
    Werner, Hauke B.
    Damkou, Alkmini
    Zampar, Silvia
    Wirths, Oliver
    Thalmann, Maik
    Simons, Mikael
    Saito, Takashi
    Saido, Takaomi
    Krueger-Burg, Dilja
    Kawaguchi, Riki
    Willem, Michael
    Haass, Christian
    Geschwind, Daniel
    Ehrenreich, Hannelore
    Stassart, Ruth
    Nave, Klaus-Armin
    NATURE, 2023, 618 (7964) : 349 - 357
  • [38] Myelin dysfunction drives amyloid-β deposition in models of Alzheimer’s disease
    Constanze Depp
    Ting Sun
    Andrew Octavian Sasmita
    Lena Spieth
    Stefan A. Berghoff
    Taisiia Nazarenko
    Katharina Overhoff
    Agnes A. Steixner-Kumar
    Swati Subramanian
    Sahab Arinrad
    Torben Ruhwedel
    Wiebke Möbius
    Sandra Göbbels
    Gesine Saher
    Hauke B. Werner
    Alkmini Damkou
    Silvia Zampar
    Oliver Wirths
    Maik Thalmann
    Mikael Simons
    Takashi Saito
    Takaomi Saido
    Dilja Krueger-Burg
    Riki Kawaguchi
    Michael Willem
    Christian Haass
    Daniel Geschwind
    Hannelore Ehrenreich
    Ruth Stassart
    Klaus-Armin Nave
    Nature, 2023, 618 : 349 - 357
  • [39] Amyloid-β, the Retina, and Mouse Models of Alzheimer Disease
    Tan, Zhiqun
    Ge, Jian
    AMERICAN JOURNAL OF PATHOLOGY, 2010, 176 (04): : 2055 - 2055
  • [40] Role of amyloid-β in Alzheimer's disease
    Smith, MA
    Perry, G
    INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, 2005, 86 (03) : 131 - 131
12345