Maternal and Paternal Age are Jointly Associated with Childhood Autism in Jamaica

被引：0

作者：

Mohammad H. Rahbar

Maureen Samms-Vaughan

Katherine A. Loveland

Deborah A. Pearson

Jan Bressler

Zhongxue Chen

Manouchehr Ardjomand-Hessabi

Sydonnie Shakespeare-Pellington

Megan L. Grove

Compton Beecher

Kari Bloom

Eric Boerwinkle

机构：

[1] The University of Texas Health Science Center at Houston (UTHealth),Division of Epidemiology, Human Genetics, and Environmental Sciences (EHGES), School of Public Health

[2] The University of Texas Health Science Center at Houston (UTHealth),Biostatistics/Epidemiology/Research Design (BERD) Core, Center for Clinical and Translational Sciences (CCTS)

[3] The University of the West Indies (UWI),Department of Child Health

[4] UTHealth,Department of Psychiatry and Behavioral Sciences, UTHealth Medical School

[5] UTHealth,Department of Psychiatry and Behavioral Sciences, Changing Lives through Autism Spectrum Services (C.L.A.S.S.) Clinic

[6] UTHealth,Center of Excellence on Development and Psychopathology

[7] UTHealth,Division of Child and Adolescent Psychiatry, Department of Psychiatry and Behavioral Sciences, UTHealth Medical School

[8] UTHealth,Human Genetics Center, School of Public Health

[9] UTHealth,Biostatistics/Epidemiology/Research Design Core, Center for Clinical and Translational Sciences

[10] The University of the West Indies,Department of Basic Medical Sciences, Caribbean Genetics

[11] UTHealth,Division of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health

来源：

Journal of Autism and Developmental Disorders | 2012年 / 42卷

关键词：

Autism spectrum disorders; Maternal age; Paternal age; Multivariate General Linear Models; Multicollinearity;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Several studies have reported maternal and paternal age as risk factors for having a child with Autism Spectrum Disorder (ASD), yet the results remain inconsistent. We used data for 68 age- and sex-matched case–control pairs collected from Jamaica. Using Multivariate General Linear Models (MGLM) and controlling for parity, gestational age, and parental education, we found a significant (p < 0.0001) joint effect of parental ages on having children with ASD indicating an adjusted mean paternal age difference between cases and controls of [5.9 years; 95% CI (2.6, 9.1)] and a difference for maternal age of [6.5 years; 95% CI (4.0, 8.9)]. To avoid multicollinearity in logistic regression, we recommend joint modeling of parental ages as a vector of outcome variables using MGLM.

引用

页码：1928 / 1938

页数：10

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