Combined treatment with statins and aminobisphosphonates extends longevity in a mouse model of human premature aging

被引：0
|
作者：
Ignacio Varela
Sandrine Pereira
Alejandro P Ugalde
Claire L Navarro
María F Suárez
Pierre Cau
Juan Cadiñanos
Fernando G Osorio
Nicolas Foray
Juan Cobo
Félix de Carlos
Nicolas Lévy
José M P Freije
Carlos López-Otín
机构：
[1] Facultad de Medicina,Departamento de Bioquímica y Biología Molecular
[2] Instituto Universitario de Oncología,Departamento de Cirugía y Especialidades Médico
[3] Universidad de Oviedo,Quirúrgicas
[4] Institut National de la Sante et de la Recherche Medicale UMR_S 910,undefined
[5] Génétique Médicale et Génomique Fonctionnelle,undefined
[6] Université de la Méditerranée,undefined
[7] Faculté de Médecine,undefined
[8] Institut National de la Sante et de la Recherche Medicale U647,undefined
[9] ID17,undefined
[10] European Synchrotron Research Facility,undefined
[11] and Instituto Asturiano de Odontología,undefined
[12] calle Julián Clavería 6,undefined
[13] Universidad de Oviedo,undefined
[14] 33006-Oviedo,undefined
来源：
Nature Medicine | 2008年 / 14卷
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摘要：
Statins and aminobisphosphonates inhibit post-translational modifications and membrane accumulation of progerin, the protein that causes Hutchinson-Gilford progeria syndrome, pointing to a potential combination therapy for this disease.
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页码：767 / 772
页数：5
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