Combined treatment with statins and aminobisphosphonates extends longevity in a mouse model of human premature aging

被引：0

作者：

Ignacio Varela

Sandrine Pereira

Alejandro P Ugalde

Claire L Navarro

María F Suárez

Pierre Cau

Juan Cadiñanos

Fernando G Osorio

Nicolas Foray

Juan Cobo

Félix de Carlos

Nicolas Lévy

José M P Freije

Carlos López-Otín

机构：

[1] Facultad de Medicina,Departamento de Bioquímica y Biología Molecular

[2] Instituto Universitario de Oncología,Departamento de Cirugía y Especialidades Médico

[3] Universidad de Oviedo,Quirúrgicas

[4] Institut National de la Sante et de la Recherche Medicale UMR_S 910,undefined

[5] Génétique Médicale et Génomique Fonctionnelle,undefined

[6] Université de la Méditerranée,undefined

[7] Faculté de Médecine,undefined

[8] Institut National de la Sante et de la Recherche Medicale U647,undefined

[9] ID17,undefined

[10] European Synchrotron Research Facility,undefined

[11] and Instituto Asturiano de Odontología,undefined

[12] calle Julián Clavería 6,undefined

[13] Universidad de Oviedo,undefined

[14] 33006-Oviedo,undefined

来源：

Nature Medicine | 2008年 / 14卷

关键词：

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中图分类号：

学科分类号：

摘要：

Statins and aminobisphosphonates inhibit post-translational modifications and membrane accumulation of progerin, the protein that causes Hutchinson-Gilford progeria syndrome, pointing to a potential combination therapy for this disease.

引用

页码：767 / 772

页数：5

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