The epigenetic landscape of Alzheimer's disease

被引:0
|
作者
Jenny Lord
Carlos Cruchaga
机构
[1] Washington University School of Medicine,Jenny Lord and Carlos Cruchaga are in the Department of Psychiatry
[2] St. Louis,undefined
[3] Missouri,undefined
[4] USA.,undefined
[5] Carlos Cruchaga is in the Hope Center Program on Protein Aggregation and Neurodegeneration,undefined
[6] Washington University School of Medicine,undefined
[7] St. Louis,undefined
[8] Missouri,undefined
[9] USA.,undefined
来源
Nature Neuroscience | 2014年 / 17卷
关键词
D O I
暂无
中图分类号
学科分类号
摘要
Two independent epigenome-wide association studies of Alzheimer's disease cohorts have identified overlapping methylation signals in four loci, ANK1, RPL13, RHBDF2 and CDH23, not previously associated with Alzheimer's disease. These studies also suggest that epigenetic changes contribute more to Alzheimer's disease than expected.
引用
收藏
页码:1138 / 1140
页数:2
相关论文
共 50 条
  • [41] The landscape of metabolic brain alterations in Alzheimer's disease
    Batra, Richa
    Arnold, Matthias
    Woerheide, Maria A.
    Allen, Mariet
    Wang, Xue
    Blach, Colette
    Levey, Allan, I
    Seyfried, Nicholas T.
    Ertekin-Taner, Nilufer
    Bennett, David A.
    Kastenmuller, Gabi
    Kaddurah-Daouk, Rima F.
    Krumsiek, Jan
    ALZHEIMERS & DEMENTIA, 2023, 19 (03) : 980 - 998
  • [42] Landscape of Phase II Trials in Alzheimer's Disease
    Lee, Alina
    Di Shan
    Castle, David
    Rajji, Tarek K.
    Ma, Clement
    JOURNAL OF ALZHEIMERS DISEASE, 2023, 96 (02) : 745 - 757
  • [43] The functional landscape of an Alzheimer's disease risk factor
    March, Z.
    Narayan, P.
    MOLECULAR BIOLOGY OF THE CELL, 2023, 34 (02) : 768 - 768
  • [44] Epigenetic Drug Repositioning for Alzheimer's Disease Based on Epigenetic Targets in Human Interactome
    Chatterjee, Paulami
    Roy, Debjani
    Rathi, Nitin
    JOURNAL OF ALZHEIMERS DISEASE, 2018, 61 (01) : 53 - 65
  • [45] Synaptic Dysfunction in Alzheimer’s Disease: Aβ, Tau, and Epigenetic Alterations
    Ke Li
    Qing Wei
    Fang-Fang Liu
    Fan Hu
    Ao-ji Xie
    Ling-Qiang Zhu
    Dan Liu
    Molecular Neurobiology, 2018, 55 : 3021 - 3032
  • [46] The fusiform gyrus exhibits an epigenetic signature for Alzheimer’s disease
    Dingailu Ma
    Irfete S. Fetahu
    Mei Wang
    Rui Fang
    Jiahui Li
    Hang Liu
    Tobin Gramyk
    Isabella Iwanicki
    Sophie Gu
    Winnie Xu
    Li Tan
    Feizhen Wu
    Yujiang G. Shi
    Clinical Epigenetics, 2020, 12
  • [47] Early epigenetic changes of Alzheimer's disease in the human hippocampus
    Blanco-Luquin, Idoia
    Acha, Blanca
    Urdanoz-Casado, Amaya
    Sanchez-Ruiz De Gordoa, Javier
    Vicuna-Urriza, Janire
    Roldan, Miren
    Labarga, Alberto
    Victoria Zelaya, Maria
    Cabello, Carolina
    Mendez-Lopez, Ivan
    Mendioroz, Maite
    EPIGENETICS, 2020, 15 (10) : 1083 - 1092
  • [48] CRISPR Epigenetic Reprogramming of Myokines as Therapy for Alzheimer's Disease
    Calvo, Thyago Leal
    Salinas-Rios, Viviana
    Burg, Ilana
    De Felice, Fernanda G.
    Urnov, Fyodor D.
    MOLECULAR THERAPY, 2024, 32 (04) : 559 - 560
  • [49] Exploring the Genetic Predisposition to Epigenetic Changes in Alzheimer's Disease
    Bryzgalov, Leonid O.
    Korbolina, Elena E.
    Merkulova, Tatiana I.
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 24 (09)
  • [50] Epigenetic Peripheral Biomarkers for Early Diagnosis of Alzheimer's Disease
    Villa, Chiara
    Stoccoro, Andrea
    GENES, 2022, 13 (08)